自突触对正弦刺激下霍奇金-赫胥黎神经元锁模结构的影响。
Influence of autapse on mode-locking structure of a Hodgkin-Huxley neuron under sinusoidal stimulus.
作者信息
Wang Hengtong, Sun Yongjuan, Li Yichen, Chen Yong
机构信息
Center of Soft Matter Physics and its Applications, Beihang University, Beijing 100191, China; School of Physics and Nuclear Energy Engineering, Beihang University, Beijing 100191, China; Institute of Theoretical Physics, Lanzhou University, Lanzhou 730000, China.
Key Laboratory of Digestive System Tumors, Lanzhou University, Lanzhou 730000, China.
出版信息
J Theor Biol. 2014 Oct 7;358:25-30. doi: 10.1016/j.jtbi.2014.05.026. Epub 2014 May 28.
We investigated the mode-locking behaviors of a Hodgkin-Huxley neuron with an autapse under sinusoidal stimulus. A neuron without an autapse can exhibit rich p:q mode-locking (i.e. p output action potentials generated by q cycles stimulations) behaviors with periodic stimuli. In the presence of the autaptic connection, the p:q mode-locking behaviors are completely reset. The autapse extends the scope of mode-locking. The autapse can enhance or suppress the status of mode-locking. Even for some specified autaptic parameters, the neuron could be driven into the sub-threshold oscillation. Our results suggested that the autapse can serve as a potential control option for adjusting the mode-locking firing behaviors. We also found that changing the delay time is much more effectively operable to regulate the response behavior than the autaptic intensity.
我们研究了具有自突触的霍奇金-赫胥黎神经元在正弦刺激下的锁模行为。没有自突触的神经元在周期性刺激下可表现出丰富的p:q锁模（即由q个周期刺激产生p个输出动作电位）行为。在存在自突触连接的情况下，p:q锁模行为会被完全重置。自突触扩展了锁模范围。自突触可以增强或抑制锁模状态。即使对于某些特定的自突触参数，神经元也可能被驱动到阈下振荡。我们的结果表明，自突触可作为调整锁模放电行为的潜在控制选项。我们还发现，改变延迟时间比自突触强度更有效地调节响应行为。
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