通过点击反应合成新型（99m）Tc标记叶酸衍生物用于单光子发射计算机断层扫描成像及其初步评价
Synthesis and preliminary evaluation of novel (99m)Tc-labeled folate derivative via click reaction for SPECT imaging.
作者信息
Guo Zhide, Zhang Pu, Song Manli, Wu Xiaowei, Liu Chang, Zhao Zuoquan, Lu Jie, Zhang Xianzhong
机构信息
Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, College of Chemistry, Beijing Normal University, 19 Xinjiekou Outer Street, Beijing 100875, China.
Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, College of Chemistry, Beijing Normal University, 19 Xinjiekou Outer Street, Beijing 100875, China; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiang׳an South Road, Xiamen 361102, China.
出版信息
Appl Radiat Isot. 2014 Sep;91:24-30. doi: 10.1016/j.apradiso.2014.04.020. Epub 2014 May 14.
The folate receptor is over expressed in a wide variety of human tumors. In this study, a novel (99m)Tc-labeled folate derivative ((99m)Tc-HYNIC-T-FA) was synthesized as a potential FR-targeting imaging probe and its efficiency was evaluated. This (99m)Tc-complex could be obtained through practical manner and showed improved in vivo characteristics compared with other radiofolates. Thus, this novel (99m)Tc-HYNIC-T-FA compound could serve as a potential imaging agent for folate receptor positive tumors.
叶酸受体在多种人类肿瘤中过度表达。在本研究中，合成了一种新型的（99m）Tc标记叶酸衍生物（（99m）Tc-HYNIC-T-FA）作为一种潜在的靶向叶酸受体的成像探针，并评估了其效能。这种（99m）Tc配合物可以通过实用的方法获得，并且与其他放射性叶酸相比，显示出改善的体内特性。因此，这种新型的（99m）Tc-HYNIC-T-FA化合物可以作为叶酸受体阳性肿瘤的一种潜在成像剂。
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