一种适用于癌症免疫编辑研究的乳腺腺癌小鼠模型。
A mammary adenocarcinoma murine model suitable for the study of cancer immunoediting.
作者信息
Pagura Lucas, Cáceres Juan Manuel, Cardinale Albertina, Scharovsky Olga Graciela, Masso Ricardo José Di, Zacarías-Fluck Mariano Federico, Rico María José, Rozados Viviana Rosa
机构信息
Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, (2000) Rosario, Argentina.
出版信息
J Biomed Sci. 2014 May 30;21(1):52. doi: 10.1186/1423-0127-21-52.
BACKGROUND
Cancer immunoediting is a dynamic process composed of three phases: elimination (EL), equilibrium (EQ) and escape (ES) that encompasses the potential host-protective and tumor-sculpting functions of the immune system throughout tumor development. Animal models are useful tools for studying diseases such as cancer. The present study was designed to characterize the interaction between mammary adenocarcinoma M-406 and CBi, CBi- and CBi/L inbred mice lines.
RESULTS
The mammary adenocarcinoma M-406 developed spontaneously in a CBi mouse. CBi/L and CBi- mice were artificially selected for body conformation from CBi. When CBi mice are s.c. challenged with M-406, tumor growths exponentially in 100% of animals, while in CBi- the tumor growths briefly and then begins a rejection process in 100% of the animals. In CBi/L the growth of the tumor shows the three phases: 51.6% in ES, 18.5% in EQ and 29.8% in EL.
CONCLUSIONS
The results obtained support the conclusion that the system M-406 plus the inbred mouse lines CBi, CBi- and CBi/L, is a good murine model to study the process of tumor immunoediting.
背景
癌症免疫编辑是一个由三个阶段组成的动态过程：清除（EL）、平衡（EQ）和逃逸（ES），它涵盖了在肿瘤发展过程中免疫系统潜在的宿主保护和肿瘤塑造功能。动物模型是研究癌症等疾病的有用工具。本研究旨在表征乳腺腺癌M-406与CBi、CBi-和CBi/L近交系小鼠之间的相互作用。
结果
乳腺腺癌M-406在一只CBi小鼠中自发产生。CBi/L和CBi-小鼠是从CBi中人工选择体型的。当CBi小鼠皮下接种M-406时，100%的动物肿瘤呈指数生长，而在CBi-中，肿瘤短暂生长，然后100%的动物开始排斥过程。在CBi/L中，肿瘤生长呈现三个阶段：51.6%处于ES阶段，18.5%处于EQ阶段，29.8%处于EL阶段。
结论
获得的结果支持以下结论，即M-406系统加上近交系小鼠CBi、CBi-和CBi/L是研究肿瘤免疫编辑过程的良好小鼠模型。
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