起源于具有BRAF V600E突变的多形性黄色星形细胞瘤的上皮样胶质母细胞瘤。
Epithelioid glioblastoma arising from pleomorphic xanthoastrocytoma with the BRAF V600E mutation.
作者信息
Tanaka Shingo, Nakada Mitsutoshi, Nobusawa Sumihito, Suzuki Satoshi O, Sabit Hemragul, Miyashita Katsuyoshi, Hayashi Yutaka
机构信息
Division of Neuroscience, Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.
出版信息
Brain Tumor Pathol. 2014 Jul;31(3):172-6. doi: 10.1007/s10014-014-0192-2. Epub 2014 Jun 4.
Pleomorphic xanthoastrocytoma (PXA) is classified by the World Health Organization as a grade II astrocytic tumor with relatively favorable prognosis among gliomas. A valine-to-glutamic acid substitution at position 600 of the serine/threonine-protein kinase BRAF (BRAF V600E) mutation, which is commonly found in PXA, has recently been detected in approximately 50% of all epithelioid glioblastoma (GBM) cases. We herein report a case of epithelioid GBM developing at the site of a left temporal PXA 13 years after the treatment of the primary tumor. The BRAF V600E mutation was detected in both tumors. These findings suggest that epithelioid GBM may arise from a PXA with a BRAF V600E mutation.
多形性黄色星形细胞瘤（PXA）被世界卫生组织归类为II级星形细胞瘤，在胶质瘤中预后相对较好。丝氨酸/苏氨酸蛋白激酶BRAF（BRAF V600E）突变的第600位缬氨酸到谷氨酸的替代，常见于PXA，最近在所有上皮样胶质母细胞瘤（GBM）病例中约50%检测到。我们在此报告一例原发性肿瘤治疗13年后，在左颞叶PXA部位发生的上皮样GBM病例。在两个肿瘤中均检测到BRAF V600E突变。这些发现表明上皮样GBM可能起源于具有BRAF V600E突变的PXA。
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