Qi Sara D, Smith Paul D, Choong Peter F
Department of Surgery, St. Vincent's Hospital, University of Melbourne, Melbourne, Victoria, Australia.
ANZ J Surg. 2014 Jun;84(6):417-23. doi: 10.1111/ans.12419.
Induced pluripotent stem cells (iPSCs) are generated from somatic cells by the exogenous expression of defined transcription factors. iPSCs share the defining features of embryonic stem cells (ESCs) in that they are able to self renew indefinitely and maintain the potential to develop into all cell types of the body. These cells have key advantages over ESCs in that they are autologous to the donor cells and can be generated from individuals at any age. iPSCs also circumvent ethical and political issues surrounding the destruction of embryos that is necessary in the isolation of ESCs. This review briefly describes the advent of iPSC technology and the concepts of nuclear reprogramming, and discusses the potential application of this powerful biological tool in both surgical research and regenerative medicine.
诱导多能干细胞（iPSC）是通过特定转录因子的外源表达从体细胞产生的。iPSC具有胚胎干细胞（ESC）的典型特征，即它们能够无限自我更新，并保持发育成身体所有细胞类型的潜力。这些细胞相对于ESC具有关键优势，因为它们与供体细胞同源，并且可以从任何年龄的个体中产生。iPSC还规避了围绕ESC分离过程中胚胎破坏的伦理和政治问题。本综述简要描述了iPSC技术的出现和核重编程的概念，并讨论了这种强大生物工具在外科研究和再生医学中的潜在应用。
