相似文献
1
3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors.
ACS Med Chem Lett. 2014 Feb 4;5(4):428-33. doi: 10.1021/ml500005m. eCollection 2014 Apr 10.
2
Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors.
Bioorg Med Chem Lett. 2006 Jan 15;16(2):349-53. doi: 10.1016/j.bmcl.2005.09.075. Epub 2005 Oct 21.
3
Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors.
Bioorg Med Chem Lett. 2008 Sep 15;18(18):5134-9. doi: 10.1016/j.bmcl.2008.07.086. Epub 2008 Jul 24.
4
4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters.
Bioorg Med Chem Lett. 2006 Aug 15;16(16):4321-5. doi: 10.1016/j.bmcl.2006.05.063. Epub 2006 Jun 9.
5
Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors.
Bioorg Med Chem Lett. 2010 Dec 1;20(23):6960-5. doi: 10.1016/j.bmcl.2010.09.124. Epub 2010 Oct 7.
6
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead.
Bioorg Med Chem Lett. 2014 Feb 15;24(4):1067-70. doi: 10.1016/j.bmcl.2014.01.013. Epub 2014 Jan 13.
7
Oleoyl-L-carnitine inhibits glycine transport by GlyT2.
Br J Pharmacol. 2013 Feb;168(4):891-902. doi: 10.1111/j.1476-5381.2012.02213.x.
8
Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1.
ACS Med Chem Lett. 2010 Jun 25;1(7):350-4. doi: 10.1021/ml1001085. eCollection 2010 Oct 14.
9
Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability.
Bioorg Med Chem Lett. 2006 Aug 15;16(16):4311-5. doi: 10.1016/j.bmcl.2006.05.058. Epub 2006 Jun 6.
10
Inhibitors of farnesyl protein transferase. 4-Amido, 4-carbamoyl, and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-bromo-8-chloro-6,11- dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine.
J Med Chem. 1998 Mar 12;41(6):877-93. doi: 10.1021/jm970462w.
引用本文的文献
1
Schizophrenia: synthetic strategies and recent advances in drug design.
Medchemcomm. 2018 Mar 16;9(5):759-782. doi: 10.1039/c7md00448f. eCollection 2018 May 1.
本文引用的文献
1
Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1.
ACS Med Chem Lett. 2010 Jun 25;1(7):350-4. doi: 10.1021/ml1001085. eCollection 2010 Oct 14.
2
Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1).
Curr Pharm Des. 2013;19(7):1311-20. doi: 10.2174/138161213804805766.
3
Glycine reuptake inhibitor RG1678: a pharmacologic characterization of an investigational agent for the treatment of schizophrenia.
Neuropharmacology. 2012 Feb;62(2):1152-61. doi: 10.1016/j.neuropharm.2011.11.008. Epub 2011 Nov 27.
4
Glycine transport inhibitors for the treatment of schizophrenia.
Open Med Chem J. 2010 May 27;4:10-9. doi: 10.2174/1874104501004010010.
5
Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors.
Bioorg Med Chem Lett. 2010 Dec 1;20(23):6960-5. doi: 10.1016/j.bmcl.2010.09.124. Epub 2010 Oct 7.
6
Pharmacological evaluation of a novel assay for detecting glycine transporter 1 inhibitors and their antipsychotic potential.
Pharmacol Biochem Behav. 2010 Dec;97(2):185-91. doi: 10.1016/j.pbb.2010.07.016. Epub 2010 Aug 1.
7
Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia.
J Med Chem. 2010 Jun 24;53(12):4603-14. doi: 10.1021/jm100210p.
8
N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia?
Brain Res Bull. 2010 Sep 30;83(3-4):108-21. doi: 10.1016/j.brainresbull.2010.04.006. Epub 2010 Apr 24.
9
Recent progress in the discovery of non-sarcosine based GlyT1 inhibitors.
Curr Top Med Chem. 2010;10(2):170-86. doi: 10.2174/156802610790410974.
10
Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET.
J Nucl Med. 2008 Aug;49(8):1328-35. doi: 10.2967/jnumed.108.051235. Epub 2008 Jul 16.
Zotero 插件