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The application of achiral/chiral coupled-column high-performance liquid chromatography to biomedical analysis.

作者信息

Wainer I W

机构信息

Pharmaceutical Division, St. Jude Children's Research Hospital, Memphis, TN 38101.

出版信息

J Pharm Biomed Anal. 1989;7(9):1033-8. doi: 10.1016/0731-7085(89)80042-1.

Abstract

The use of achiral/chiral coupled-column HPLC in the direct analysis of the enantiomers of chiral drugs in biological samples is reviewed. The method has been applied to a study of the pharmacokinetics of (+)- and (-)-terbutaline, the resolution of the stereoisomers of leucovorin and the determination of warfarin enantiomers in serum.

摘要

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