Wainer I W
Pharmaceutical Division, St. Jude Children's Research Hospital, Memphis, TN 38101.
J Pharm Biomed Anal. 1989;7(9):1033-8. doi: 10.1016/0731-7085(89)80042-1.
The use of achiral/chiral coupled-column HPLC in the direct analysis of the enantiomers of chiral drugs in biological samples is reviewed. The method has been applied to a study of the pharmacokinetics of (+)- and (-)-terbutaline, the resolution of the stereoisomers of leucovorin and the determination of warfarin enantiomers in serum.