正中神经大鼠模型中组织形态计量学与运动神经ography的相关性分析。需注意，你原文中的“neurography”可能有误，常见的是“neurograph”（神经图），若有误请修正后让我翻译，以使译文更准确。

Correlation analysis of histomorphometry and motor neurography in the median nerve rat model.

作者信息

Manoli Theodora, Werdin Frank, Gruessinger Hannes, Sinis Nektarios, Schiefer Jennifer Lynn, Jaminet Patrick, Geuna Stefano, Schaller Hans-Eberhard

机构信息

Clinic of Hand, Plastic, and Reconstructive Surgery with Burn Unit, BG-Trauma Centre, University of Tuebingen, Schnarrenbergstr. 95, 72076 Tuebingen, Germany.

Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano (TO), Azienda Ospedaliera San Luigi - Regione Gonzole 10, 10043 Turin, Italy.

出版信息

Eplasty. 2014 Apr 9;14:e17. eCollection 2014.

PMID:24904711

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3984537/

Abstract

OBJECTIVE

Standard methods to evaluate the functional regeneration after injury of the rat median nerve are insufficient to identify any further differences of axonal nerve regeneration after restitution of motor recovery is completed. An important complementary method for assessing such differences is a histomorphometric analysis of the distal to lesion nerve fibers. Recently, an electrophysiological method has been proposed as a sensitive method to examine the quality of axonal nerve regeneration.

METHODS

A linear regression analysis has been performed to correlate histomorphometric and neurographic data originating from 31 rats subjected to neurotmesis and immediate reconstruction of their right median nerve.

RESULTS

A significant linear correlation between the velocity of neuromuscular conduction and the total number of nerve fibers (P = .037) as well as between the amplitude of compound muscle action potential and the total number of nerve fibers (P = .026) has been identified. Interestingly, a significant correlation between the velocity of neuromuscular conduction and the square root of the cross-sectional area of the nerve could be found (P = .008). This corresponds to a linear correlation between the velocity of neuromuscular conduction and the radius of the nerve.

CONCLUSION

These results contribute in a better interpretation of morphological predictors of nerve regeneration and verify the previously described electrophysiological assessment in the median nerve rat model as a valid method.

摘要

目的

评估大鼠正中神经损伤后功能再生的标准方法，不足以识别运动功能恢复完成后轴突神经再生的任何进一步差异。评估此类差异的一种重要补充方法是对损伤部位远端神经纤维进行组织形态计量分析。最近，一种电生理方法被提议作为检测轴突神经再生质量的敏感方法。

方法

对31只接受神经切断术并立即重建其右正中神经的大鼠的组织形态计量学和神经图像数据进行线性回归分析。

结果

已确定神经肌肉传导速度与神经纤维总数之间存在显著线性相关性（P = 0.037），以及复合肌肉动作电位幅度与神经纤维总数之间存在显著线性相关性（P = 0.026）。有趣的是，可发现神经肌肉传导速度与神经横截面积的平方根之间存在显著相关性（P = 0.008）。这对应于神经肌肉传导速度与神经半径之间的线性相关性。