Shin Dong Yeob, Kim Kwang Joon, Chang Sooyun, Kim Hyunki, Hwang Sena, Kim Wonjin, Bae Jaehyun, Park Seulkee, Kang Sang-Wook, Chung Woong Youn, Lee Eun Jig
Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Severance Executive Healthcare Clinic, Yonsei University Health System, Seoul, Republic of Korea.
Head Neck. 2015 Nov;37(11):1590-5. doi: 10.1002/hed.23793. Epub 2014 Aug 1.
The purpose of this study was to investigate the correlation between B-type Raf (BRAF) kinase mutation and clinicopathological features of follicular variant of papillary thyroid carcinoma (PTC).
Eighty-four patients with pathologically confirmed follicular variant of PTC, who underwent a preoperative BRAF(V600E) study, were analyzed. Clinicopathological parameters and ultrasonographic features were compared between the BRAF(V600E) -positive and negative groups.
A total of 41.7% of the patients showed BRAF(V600E) . The BRAF(V600E) -positive group showed the smaller tumor size (7.3 ± 3.6 mm vs 10.7 ± 8.9 mm; p = .018) and the more frequent multifocality (25.7% vs 8.2%; p = .028). Follicular variant of PTC with BRAF(V600E) showed suspicious ultrasonographic features (88.6% vs 57.1%; p = .002) more frequently. BRAF(V600E) positivity is associated with multifocality after adjusting for age, sex, the presence of suspicious ultrasonographic features, pathological tumor size, and thyrotropin level.
BRAF(V600E) was correlated with smaller tumor size and suspicious ultrasonographic features in follicular variant of PTC. BRAF(V600E) was a significant parameter for predicting multifocality of follicular variant of PTC.
本研究旨在探讨B型Raf（BRAF）激酶突变与甲状腺乳头状癌滤泡变体（PTC）临床病理特征之间的相关性。
对84例经病理确诊为PTC滤泡变体且术前行BRAF（V600E）检测的患者进行分析。比较BRAF（V600E）阳性组和阴性组的临床病理参数及超声特征。
共41.7%的患者显示BRAF（V600E）阳性。BRAF（V600E）阳性组肿瘤体积较小（7.3±3.6mm对10.7±8.9mm；p = 0.018），多灶性更常见（25.7%对8.2%；p = 0.028）。BRAF（V600E）阳性的PTC滤泡变体更频繁地表现出可疑超声特征（88.6%对57.1%；p = 0.002）。在校正年龄、性别、可疑超声特征的存在、病理肿瘤大小和促甲状腺激素水平后，BRAF（V600E）阳性与多灶性相关。
BRAF（V600E）与PTC滤泡变体中较小的肿瘤体积和可疑超声特征相关。BRAF（V600E）是预测PTC滤泡变体多灶性的重要参数。
