盘状结构域蛋白5在细胞极性维持与癌症发展中的作用
DLG5 in cell polarity maintenance and cancer development.
作者信息
Liu Jie, Li Juan, Ren Yu, Liu Peijun
机构信息
1. Center for Translational Medicine, the First Affiliated Hospital of Xian Jiaotong University College of Medicine;
2. Department of Surgical Oncology, the First Affiliated Hospital of Xian Jiaotong University College of Medicine.
出版信息
Int J Biol Sci. 2014 May 3;10(5):543-9. doi: 10.7150/ijbs.8888. eCollection 2014.
Failure in establishment and maintenance of epithelial cell polarity contributes to tumorigenesis. Loss of expression and function of cell polarity proteins is directly related to epithelial cell polarity maintenance. The polarity protein discs large homolog 5 (DLG5) belongs to a family of molecular scaffolding proteins called Membrane Associated Guanylate Kinases (MAGUKs). As the other family members, DLG5 contains the multi-PDZ, SH3 and GUK domains. DLG5 has evolved in the same manner as DLG1 and ZO1, two well-studied MAGUKs proteins. Just like DLG1 and ZO1, DLG5 plays a role in cell migration, cell adhesion, precursor cell division, cell proliferation, epithelial cell polarity maintenance, and transmission of extracellular signals to the membrane and cytoskeleton. Since the roles of DLG5 in inflammatory bowel disease (IBD) and Crohn's disease (CD) have been reviewed, here, our review focuses on the roles of DLG5 in epithelial cell polarity maintenance and cancer development.
上皮细胞极性的建立和维持失败会促进肿瘤发生。细胞极性蛋白表达和功能的丧失与上皮细胞极性维持直接相关。极性蛋白盘大同源物5（DLG5）属于一个名为膜相关鸟苷酸激酶（MAGUKs）的分子支架蛋白家族。与其他家族成员一样，DLG5包含多个PDZ、SH3和GUK结构域。DLG5与另外两个经过充分研究的MAGUKs蛋白DLG1和ZO1以相同的方式进化。与DLG1和ZO1一样，DLG5在细胞迁移、细胞黏附、前体细胞分裂、细胞增殖、上皮细胞极性维持以及细胞外信号向膜和细胞骨架的传递中发挥作用。由于DLG5在炎症性肠病（IBD）和克罗恩病（CD）中的作用已有综述，在此，我们的综述重点关注DLG5在上皮细胞极性维持和癌症发展中的作用。
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