爱泼斯坦-巴尔病毒相关胃癌中的表观遗传失调：疾病与治疗
Epigenetic dysregulation in Epstein-Barr virus-associated gastric carcinoma: disease and treatments.
作者信息
Yau Tung On, Tang Ceen-Ming, Yu Jun
机构信息
Tung On Yau, Ceen-Ming Tang, Jun Yu, Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
出版信息
World J Gastroenterol. 2014 Jun 7;20(21):6448-56. doi: 10.3748/wjg.v20.i21.6448.
Abstract
Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) comprises nearly 10% of gastric carcinoma cases worldwide. Recently, it was recognised to have unique clinicopathologic characteristics, including male predominance, lower rates of lymph node involvement, and better prognosis. EBVaGC is further characterised by abnormal hypermethylation of tumour suppressor gene promoter regions, causing down-regulation of their expression. In the present review, we critically discuss the role of EBV in gastric carcinogenesis, summarising the role of viral proteins and microRNAs with respect to aberrant methylation in EBVaGC. Given the role of epigenetic dysregulation in tumourigenesis, epigenetic modifiers may represent a novel therapeutic strategy.
摘要
爱泼斯坦-巴尔病毒（EBV）相关胃癌（EBVaGC）在全球胃癌病例中占近10%。最近，人们认识到它具有独特的临床病理特征，包括男性居多、淋巴结受累率较低以及预后较好。EBVaGC的进一步特征是肿瘤抑制基因启动子区域异常高甲基化，导致其表达下调。在本综述中，我们批判性地讨论了EBV在胃癌发生中的作用，总结了病毒蛋白和微小RNA在EBVaGC异常甲基化方面的作用。鉴于表观遗传失调在肿瘤发生中的作用，表观遗传修饰剂可能代表一种新的治疗策略。
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