LINE-1 逆转座子导致胎儿卵母细胞损耗的一线证据。

LINE-1 of evidence for fetal oocyte attrition by retrotransposon.

机构信息

Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

出版信息

Dev Cell. 2014 Jun 9;29(5):501-502. doi: 10.1016/j.devcel.2014.05.017.

DOI:10.1016/j.devcel.2014.05.017

Abstract

Fetal oocytes in mammals undergo extensive apoptosis during development. In this issue of Developmental Cell, Malki et al. (2014) provide insight into how and why such massive oocyte loss occurs through the demonstration that the expression level of LINE-1 retrotransposon defines the survival threshold and thus viability of fetal oocytes.

摘要

哺乳动物的胚胎卵母细胞在发育过程中会经历广泛的凋亡。在本期《发育细胞》中，Malki 等人（2014 年）通过证明 LINE-1 反转录转座子的表达水平决定了胚胎卵母细胞的存活阈值和生存能力，从而深入了解了这种大量卵母细胞丢失发生的原因和方式。