Panda Manasa R, Lecluyse Wendy, Tan Christine M, Jürgens Tim, Meddis Ray
* Department of Psychology, University of Essex , Colchester , UK.
Int J Audiol. 2014 Oct;53(10):699-709. doi: 10.3109/14992027.2014.917206. Epub 2014 Jun 10.
Objective: Our aim was to explore the usage of individualized computer models to simulate hearing loss based on detailed psychophysical assessment and to offer hypothetical diagnoses of the underlying pathology.
Individualized computer models of normal and impaired hearing were constructed and evaluated using the psychophysical data obtained from human listeners. Computer models of impaired hearing were generated to reflect the hypothesized underlying pathology (e.g. dead regions, outer hair cell dysfunction, or reductions in endocochlear potential). These models were evaluated in terms of their ability to replicate the original patient data.
Auditory profiles were measured for two normal and five hearing-impaired listeners using a battery of three psychophysical tests (absolute thresholds, frequency selectivity, and compression).
The individualized computer models were found to match the data. Useful fits to the impaired profiles could be obtained by changing only a single parameter in the model of normal hearing. Sometimes, however, it was necessary to include an additional dead region.
The creation of individualized computer models of hearing loss can be used to simulate auditory profiles of impaired listeners and suggest hypotheses concerning the underlying peripheral pathology.
目的：我们的目的是探索基于详细心理物理学评估的个体化计算机模型在模拟听力损失方面的应用，并对潜在病理状况进行假设性诊断。
使用从人类受试者获得的心理物理学数据构建并评估正常听力和听力受损的个体化计算机模型。生成听力受损的计算机模型以反映假设的潜在病理状况（例如死区、外毛细胞功能障碍或内淋巴电位降低）。根据这些模型复制原始患者数据的能力对其进行评估。
使用一组三项心理物理学测试（绝对阈值、频率选择性和压缩）对两名正常听力和五名听力受损的受试者测量听觉特征。
发现个体化计算机模型与数据匹配。通过仅改变正常听力模型中的一个参数就可以获得与受损特征的良好拟合。然而，有时有必要纳入一个额外的死区。
创建听力损失的个体化计算机模型可用于模拟听力受损受试者的听觉特征，并提出有关潜在外周病理状况的假设。
