Malandrino N, Miceli A, Leggio L, Mingrone G, Capristo E
Institute of Internal Medicine, Metabolic Diseases Outpatient Unit, Catholic University of Rome, Rome, Italy.
Humanitas Clinical and Research Center, Rozzano (MI), Italy.
Exp Clin Endocrinol Diabetes. 2014 Oct;122(9):540-3. doi: 10.1055/s-0034-1376965. Epub 2014 Jun 11.
Hashimoto's thyroiditis is a chronic inflammatory condition often associated with changes in appetite and body composition. Ghrelin is an orexigenic peptide involved in the regulation of appetite and food intake. A possible role of ghrelin in mediating inflammation has been suggested. A few contrasting published data are available on the relationship between thyroid status and circulating ghrelin in patients affected by Hashimoto's thyroiditis. The aim of the present case-control study was to provide additional evidence on the relationship between thyroid status and plasma ghrelin levels in post-treatment euthyroid female patients with Hashimoto's thyroiditis, compared to healthy controls.
25 women [age 46.6±10.6 years; Body Mass Index 26.3±3.8 kg/m²] affected by overt hypothyroidism due to Hashimoto's thyroiditis were studied after thyroid hormones and body weight were already normalized for at least 2 months following L-thyroxine replacement. 25 healthy women (age 40.2±6.4 years; Body Mass Index 26.2±4.0 kg/m²) served as the control group. Blood levels of thyroid hormones, thyroid peroxidase antibodies, thyroglobulin antibodies and ghrelin were determined. Fat mass, fat-free mass and high-density lipoprotein cholesterol were also assessed.
Circulating ghrelin levels were significantly higher in patients vs. control subjects (p<0.001). No differences were found in metabolic parameters (body mass index, fat mass, fat-free mass, high-density lipoprotein cholesterol) between groups.
The present study provides additional evidence of hyperghrelinemia status in post-treatment euthyroid patients affected by Hashimoto's thyroiditis.
桥本甲状腺炎是一种慢性炎症性疾病，常伴有食欲和身体成分的变化。胃饥饿素是一种参与食欲和食物摄入调节的促食欲肽。胃饥饿素在介导炎症反应中可能发挥作用。关于桥本甲状腺炎患者甲状腺状态与循环胃饥饿素之间的关系，已有一些相互矛盾的 published data。本病例对照研究的目的是，与健康对照相比，为桥本甲状腺炎治疗后甲状腺功能正常的女性患者甲状腺状态与血浆胃饥饿素水平之间的关系提供更多证据。
研究 25 名因桥本甲状腺炎导致明显甲状腺功能减退的女性[年龄 46.6±10.6 岁；体重指数 26.3±3.8kg/m²]，她们在左甲状腺素替代治疗后甲状腺激素和体重已正常化至少 2 个月。25 名健康女性（年龄 40.2±6.4 岁；体重指数 26.2±4.0kg/m²）作为对照组。测定甲状腺激素、甲状腺过氧化物酶抗体、甲状腺球蛋白抗体和胃饥饿素的血液水平。还评估了脂肪量、去脂体重和高密度脂蛋白胆固醇。
患者的循环胃饥饿素水平显著高于对照组（p<0.001）。两组之间的代谢参数（体重指数、脂肪量、去脂体重、高密度脂蛋白胆固醇）没有差异。
本研究为桥本甲状腺炎治疗后甲状腺功能正常的患者高胃饥饿素血症状态提供了更多证据。
