Biofluid Mechanics Laboratory, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Expert Rev Med Devices. 2014 Jul;11(4):361-73. doi: 10.1586/17434440.2014.925395.
Coils and flow diverters or stents are devices successfully used to treat cerebral aneurysms. Treatment aims to reduce intra-aneurysmal flow, thereby separating the aneurysmal sac from the blood circulation. The focus and this manuscript combining literature review and our original research is an analysis of changes in aneurysmal hemodynamics caused by endovascular treatment devices. Knowledge of post-treatment hemodynamics is a path to successful long-term treatment. Summarizing findings on hemodynamic impact of treatment devices, we conclude: coiling and stenting do not affect post-treatment intra-aneurysmal pressure, but significantly alter aneurysmal hemodynamics through flow reduction and a change in flow structure. The impact of treatment devices on aneurysmal flow depends, however, on a set of parameters including device geometry, course of placement, parent vessel and aneurysm geometry.
线圈和血流导向装置或支架是成功用于治疗脑动脉瘤的器械。治疗旨在降低颅内动脉瘤内的血流,从而将动脉瘤囊与血液循环分隔开。重点和本文结合文献综述和我们的原创研究,是分析血管内治疗器械引起的动脉瘤血流动力学变化。了解治疗后的血流动力学是成功进行长期治疗的途径。总结治疗器械对血流动力学影响的研究结果,我们得出结论:线圈栓塞和支架置入术并不影响治疗后的颅内动脉瘤内压力,但通过减少血流和改变血流结构显著改变动脉瘤的血流动力学。然而,治疗器械对动脉瘤血流的影响取决于一系列参数,包括器械的几何形状、放置过程、载瘤血管和动脉瘤的几何形状。