编织型血管内桥接(WEB)装置用于破裂颅内宽颈动脉瘤的血管内治疗:单中心经验

Woven Endobridge (WEB) Device for endovascular treatment of ruptured intracranial wide-neck aneurysms: a single-center experience.

作者信息

Caroff Jildaz, Mihalea Cristian, Dargento Francesco, Neki Hiroaki, Ikka Léon, Benachour Nidhal, Moret Jacques, Spelle Laurent

机构信息

Beaujon Medical Center, NEURI - Interventional Neuroradiology, 100, boulevard Général Leclerc, 92110, Clichy, France,

出版信息

Neuroradiology. 2014 Sep;56(9):755-61. doi: 10.1007/s00234-014-1390-7. Epub 2014 Jun 15.

Abstract

INTRODUCTION

Endovascular treatment of ruptured wide-neck bifurcation aneurysms presents a challenge. While still under evaluation, the Woven Endobridge (WEB) aneurysm embolization system has so far shown promising results in the treatment of complex bifurcation aneurysms. We aimed to evaluate the feasibility and short-term follow-up of endovascular treatment of ruptured wide-neck aneurysm with the WEB device.

METHODS

Six patients referred to our institution for acute symptomatic subarachnoid hemorrhage (SAH) and treated with the WEB device were enrolled in this study. Clinical presentations, technical details, intraoperative and postoperative complications, and outcomes were recorded. Immediate and 3-month angiographic results were also evaluated.

RESULTS

Three middle cerebral artery (MCA) and three anterior communicating artery aneurysms were treated between 1 and 14 days after rupturing. Average dome width was 5.8 mm (range 5-7), average neck size was 4.5 mm (range 4-5), and average dome-to-neck ratio was 1.3 (range 1-1.7). The WEB system was the exclusive treatment and was successfully deployed in all cases. Per procedural thromboembolic events occurred in two cases and were treated with intra-arterial administration of antiplatelet agents without any clinical consequences. The modified Rankin Scale (mRS) score at discharge was 0 for all patients. The 3-month angiographic follow-up showed adequate occlusion in four of our six patients (67 %).

CONCLUSION

From this preliminary study, the high feasibility rate and lack of need for systematic antiplatelet agents favor the WEB device providing a solution for endovascular treatment of ruptured wide-neck bifurcation aneurysms during the acute phase. However, further studies are needed to evaluate the complication rate and long-term efficiency.

摘要

引言

破裂性宽颈分叉动脉瘤的血管内治疗具有挑战性。虽然仍在评估中,但编织型血管内桥接(WEB)动脉瘤栓塞系统迄今为止在复杂分叉动脉瘤的治疗中已显示出有前景的结果。我们旨在评估使用WEB装置对破裂性宽颈动脉瘤进行血管内治疗的可行性和短期随访情况。

方法

本研究纳入了6例因急性症状性蛛网膜下腔出血(SAH)转诊至我院并接受WEB装置治疗的患者。记录临床表现、技术细节、术中和术后并发症及结果。还评估了即刻和3个月时的血管造影结果。

结果

在破裂后1至14天内对3例大脑中动脉(MCA)动脉瘤和3例前交通动脉瘤进行了治疗。平均瘤顶宽度为5.8毫米(范围5 - 7),平均瘤颈大小为4.5毫米(范围4 - 5),平均瘤顶与瘤颈比值为1.3(范围1 - 1.7)。WEB系统是唯一的治疗方法,所有病例均成功植入。两例发生了围手术期血栓栓塞事件,通过动脉内给予抗血小板药物进行治疗,未产生任何临床后果。所有患者出院时改良Rankin量表(mRS)评分为0。3个月时的血管造影随访显示,6例患者中有4例(67%)实现了充分栓塞。

结论

从这项初步研究来看,高可行性以及无需系统性使用抗血小板药物有利于WEB装置为急性期破裂性宽颈分叉动脉瘤的血管内治疗提供一种解决方案。然而,需要进一步研究来评估并发症发生率和长期疗效。

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