儿科移植与免疫耐受：过去、现在与未来。

Pediatric transplantation and tolerance: past, present, and future.

作者信息

Kamran Hejazi Kenari Seyed, Mirzakhani Hooman, Saidi Reza F

机构信息

Division of Organ Transplantation, Department of Surgery, Alpert Medical School of Brown University, Providence, RI, USA.

出版信息

Pediatr Transplant. 2014 Aug;18(5):435-45. doi: 10.1111/petr.12301. Epub 2014 Jun 14.

DOI:10.1111/petr.12301

PMID:24931282

Abstract

Solid organ transplantation is the treatment of choice in children with end-stage organ failure. With improving methods of transplant surgery and post-transplant care, transplantation is more frequently performed worldwide. However, lifelong and non-specific suppression of the recipient's immune system is a cause of significant morbidity in children, including infection, diabetes, and cancer. There is a great need to develop IS minimization/withdrawal and tolerance induction approaches.

摘要

实体器官移植是终末期器官衰竭患儿的首选治疗方法。随着移植手术和移植后护理方法的不断改进，移植手术在全球范围内的开展越来越频繁。然而，对受者免疫系统进行终身且非特异性的抑制是儿童出现严重发病情况的一个原因，包括感染、糖尿病和癌症。迫切需要开发减少免疫抑制/停用免疫抑制及诱导免疫耐受的方法。