奥沙利铂与溶菌酶反应形成的复合物的X射线结构。
The X-ray structure of the complex formed in the reaction between oxaliplatin and lysozyme.
作者信息
Messori Luigi, Marzo Tiziano, Merlino Antonello
机构信息
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy.
出版信息
Chem Commun (Camb). 2014 Aug 7;50(61):8360-2. doi: 10.1039/c4cc02254h.
The X-ray structure of the adduct formed between oxaliplatin and the model protein hen egg white lysozyme is reported here. The structure is compared with those of cisplatin and carboplatin derivatives, previously solved. Relevant changes are highlighted among these crystal structures that are suggestive of significant differences in the reactivity of platinum drugs with this protein; possible biological implications are discussed.
本文报道了奥沙利铂与模型蛋白鸡蛋清溶菌酶形成的加合物的X射线结构。将该结构与之前解析的顺铂和卡铂衍生物的结构进行了比较。在这些晶体结构中突出显示了相关变化，这些变化表明铂类药物与该蛋白的反应性存在显著差异；并讨论了可能的生物学意义。
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