Li Chengjun, Song Xiaowen, Chen Xuhong, Liu Xing, Sang Ming, Wu Wei, Yun Xiaopei, Hu Xingxing, Li Bin
Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.
Genomics. 2014 Jul;104(1):58-67. doi: 10.1016/j.ygeno.2014.06.002. Epub 2014 Jun 19.
The body louse has the smallest genome size among the known genome-sequenced insects. Here, 81 GPCRs were identified in Pediculus humanus humanus, 56, 14, 6 and 5 GPCRs for family-A, -B, -C and -D, respectively. These GPCRs constitute the comparable repertoire of GPCRs with other insects. Moreover, it contains a more complete set of neuropeptide and protein hormone receptors not even than Acyrthosiphon pisum but also Drosophila melanogaster, for example, Sulfakinin, Corazonin, Trissin and PTHRL only presented in P. h. humanus but lost either in A. pisum or D. melanogaster. However, it has less duplication among the sub-families. Meanwhile, ACP, AVPL, HE6 receptors and Boss were also absent from P. h. humanus. These results indicated that the repertoire of GPCRs in P. h. humanus were not affected by its smallest genome size, and further suggested that P. h. humanus has a relatively original and concise GPCR regulation system.
体虱在已知基因组测序的昆虫中基因组大小最小。在此，在人体虱中鉴定出81个G蛋白偶联受体（GPCR），其中A、B、C和D家族的GPCR分别有56个、14个、6个和5个。这些GPCR构成了与其他昆虫相当的GPCR库。此外，它甚至比豌豆蚜和黑腹果蝇都含有更完整的神经肽和蛋白质激素受体集，例如，速激肽、心钠素、Trissin和PTHRL仅在人体虱中存在，而在豌豆蚜或黑腹果蝇中缺失。然而，它在亚家族之间的重复较少。同时，人体虱中也不存在ACP、AVPL、HE6受体和Boss。这些结果表明，人体虱中的GPCR库不受其最小基因组大小的影响，进一步表明人体虱具有相对原始和简洁的GPCR调节系统。
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