Voropaeva O F, Shokin Yu I, Nepomnyashchikh L M, Senchukova S R
Institute of Computation Technologies, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia,
Bull Exp Biol Med. 2014 Jun;157(2):291-4. doi: 10.1007/s10517-014-2548-3. Epub 2014 Jun 22.
Mathematical simulation of the time course of p53 and Mdm2 protein concentrations during their interactions was carried out. The system states corresponding to threatened uncontrolled apoptotic cell death accelerating aging processes and to situation with hypersuppression of p53-dependent apoptosis fraught with high risk of cancer were modeled. New data indicate the possibility of description (within the framework of mathematical model used in the study) of the p53 and Mdm2 proteins feedback mechanism, which could guarantee adequate reaction to serious DNA damage.
对p53和Mdm2蛋白相互作用过程中的浓度随时间变化进行了数学模拟。模拟了对应于威胁性的不受控制的凋亡性细胞死亡加速衰老过程的系统状态，以及对应于p53依赖性凋亡超抑制且伴有高癌症风险情况的系统状态。新数据表明（在该研究中使用的数学模型框架内）p53和Mdm2蛋白反馈机制具有可描述性，这可以保证对严重DNA损伤做出适当反应。
