使海藻糖去对称化以合成海藻糖糖脂的策略。
Strategies for desymmetrising trehalose to synthesise trehalose glycolipids.
作者信息
Wu Chia-Hui, Wang Cheng-Chung
机构信息
Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program (TIGP), Academia Sinica, Taipei 115, Taiwan.
出版信息
Org Biomol Chem. 2014 Aug 14;12(30):5558-62. doi: 10.1039/c4ob00587b. Epub 2014 Jun 23.
PMID:24953248
Abstract
The desymmetrisation and regioselective protection of trehalose are major challenges in the chemical synthesis of biologically essential trehalose glycolipids. We reviewed the literature on desymmetrising trehalose to synthesise trehalose glycolipids and highlighted an efficient regioselective 6-O-phosphorylation method that can be applied to synthesise asymmetric trehalose glycolipids.
摘要
海藻糖的去对称化和区域选择性保护是生物必需的海藻糖糖脂化学合成中的主要挑战。我们回顾了关于海藻糖去对称化以合成海藻糖糖脂的文献，并着重介绍了一种可用于合成不对称海藻糖糖脂的高效区域选择性6-O-磷酸化方法。
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