Zöller Bengt, Li Xinjun, Sundquist Jan, Sundquist Kristina
Center for Primary Health Care Research, Lund University, Malmö, Sweden.
Center for Primary Health Care Research, Lund University, Malmö, Sweden.
Eur J Cancer. 2014 Sep;50(13):2319-27. doi: 10.1016/j.ejca.2014.05.018. Epub 2014 Jun 18.
Familial clustering of prostate, breast and colorectal cancer is well established, but the familial risk of these cancers has not been determined among adoptees. The aim was to disentangle the contributions of genetic and environmental factors to the familial transmission of prostate, breast and colorectal cancer.
The Swedish Multi-Generation Register was used to follow all adoptees born between 1932 and 1969 (n=70,965) for prostate, breast and colorectal cancer from January 1958 up to December 2010. The risk of prostate, breast and colorectal cancer was estimated in adoptees with at least one biological parent with the same cancer type compared with adoptees without a biological parent with the same cancer type. The risk of cancer was also determined in adoptees with at least one adoptive parent with cancer compared with adoptees with an adoptive parent without cancer.
Adoptees with at least one biological parent with prostate, breast or colorectal cancer were more likely to have cancer of the same type than adoptees with biological parents not affected by these respective cancer types (standardised incidence ratio=SIR: 1.8 [95% confidence interval 1.2-2.7], 2.0 [1.6-2.5] and 1.9 [1.2-2.9], respectively). In contrast, adoptees with at least one adoptive parent with prostate, breast or colorectal cancer were not at an increased risk of these respective cancer types (SIR=1.2 [0.94-1.6], 0.97 [0.71-1.3], and 1.1 [0.71-1.5], respectively).
The findings of the study support the importance of genetic/biological factors in the familial transmission of prostate, breast and colorectal cancer.
前列腺癌、乳腺癌和结直肠癌的家族聚集性已得到充分证实，但这些癌症在被收养者中的家族风险尚未确定。目的是厘清遗传和环境因素对前列腺癌、乳腺癌和结直肠癌家族传播的影响。
利用瑞典多代登记册，对1932年至1969年出生的所有被收养者（n = 70965）从1958年1月至2010年12月进行前列腺癌、乳腺癌和结直肠癌的随访。将至少有一位亲生父母患相同癌症类型的被收养者与没有亲生父母患相同癌症类型的被收养者相比，评估前列腺癌、乳腺癌和结直肠癌的风险。还将至少有一位养父母患癌症的被收养者与养父母无癌症的被收养者相比，确定癌症风险。
至少有一位亲生父母患前列腺癌、乳腺癌或结直肠癌的被收养者，比亲生父母未受这些相应癌症类型影响的被收养者更易患相同类型的癌症（标准化发病率比=SIR：分别为1.8[95%置信区间1.2 - 2.7]、2.0[1.6 - 2.5]和1.9[1.2 - 2.9]）。相比之下，至少有一位养父母患前列腺癌、乳腺癌或结直肠癌的被收养者，患这些相应癌症类型的风险并未增加（SIR分别为1.2[0.94 - 1.6]、0.97[0.71 - 1.3]和1.1[0.71 - 1.5]）。
该研究结果支持遗传/生物学因素在前列腺癌、乳腺癌和结直肠癌家族传播中的重要性。
