Ma Jun-Zeng, Yang Xing-Wei, Zhang Jing-Jing, Liu Xia, Deng Li-Lan, Shen Xiao-Ling, Xu Gang
Southwest Forestry University, Kunming, 650224 People's Republic of China ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.
Nat Prod Bioprospect. 2014 Jun;4(3):175-80. doi: 10.1007/s13659-014-0021-7. Epub 2014 May 14.
A new stigmasterol type natural product, viburodorol A (1), along with eleven known sterols and terpenoids (2-12), were isolated from the aerial parts of Viburnum odoratissimum. The structure of 1 was elucidated on the basis of comprehensive spectroscopic analysis. It's noteworthy that compound 2, the major constituent of this plant, can significantly stimulate glucose absorption in insulin resistant HepG2 cells without affecting cell viability. Furthermore, this compound can also restore the glucose absorption in DXMS-induced insulin resistant 3T3-L1 cells.
从香荚蒾的地上部分分离出一种新的豆甾醇型天然产物——荚蒾醇A（1），以及十一种已知的甾醇和萜类化合物（2 - 12）。通过综合光谱分析确定了1的结构。值得注意的是，该植物的主要成分化合物2能显著刺激胰岛素抵抗的HepG2细胞吸收葡萄糖，且不影响细胞活力。此外，该化合物还能恢复地塞米松诱导的胰岛素抵抗3T3 - L1细胞的葡萄糖吸收。
