Raisis Anthea L, Smart Lisa, Drynan Eleanor, Hosgood Giselle
College Of Veterinary Medicine, Murdoch University, Perth, WA, Australia.
Vet Anaesth Analg. 2015 Mar;42(2):133-41. doi: 10.1111/vaa.12190. Epub 2014 Jun 25.
To compare adequacy of oxygen delivery and severity of shock during maintenance of anaesthesia with isoflurane or alfaxalone infusion in greyhounds experiencing blood loss.
Prospective, randomised study.
Twenty-four greyhounds (ASA I).
All greyhounds were premedicated with methadone (0.2 mg kg(-1) ) intramuscularly. Anaesthesia was induced with alfaxalone 2.5 mg kg(-1) intravenously. Following endotracheal intubation, the dogs were connected to an anaesthetic circle circuit delivering oxygen. Dogs were allocated to receive inhaled isoflurane or an intravenous infusion of alfaxalone for maintenance of anaesthesia. Isoflurane was initially administered to achieve an end-tidal concentration of 1.4% and alfaxalone was initially administered at 0.13 mg kg(-1) minute(-1) . The dose of isoflurane or alfaxalone was adjusted during instrumentation to produce a clinically equivalent depth of anaesthesia. All dogs were mechanically ventilated to normocapnia (Pa CO2 35-40 mmHg; 4.67-5.33 kPa). Passive warming maintained core body temperature between 37 and 38 °C. Measured and calculated indices of cardiovascular function, including mean arterial blood pressure (MAP), cardiac index (CI), systemic vascular resistance index (SVRI), oxygen delivery index (D˙O2I), oxygen consumption index (V˙O2I) and oxygen extraction ratio (OER), were determined at baseline (60 minutes after start of anaesthesia) and after removal of 32 mL kg(-1) and 48 mL kg(-1) of blood.
In all dogs, blood loss resulted in a significant decrease in MAP, CI, D˙O2 , and a significant increase in SVRI, V˙O2I , and OER. The changes in each of the indices did not differ significantly between dogs receiving isoflurane and dogs receiving alfaxalone.
No difference in oxygen delivery or severity of shock was observed when either inhaled isoflurane or intravenous alfaxalone infusion was used for maintenance of anaesthesia in greyhounds experiencing blood loss. There appears to be no clinical advantage to choosing one anaesthetic agent for maintenance of anaesthesia over the other in a dog experiencing blood loss.
比较在失血的灵缇犬麻醉维持期间，异氟烷或阿法沙龙输注时的氧输送充足情况和休克严重程度。
前瞻性随机研究。
24只灵缇犬（美国麻醉医师协会I级）。
所有灵缇犬均肌肉注射美沙酮（0.2毫克/千克）进行术前用药。静脉注射2.5毫克/千克阿法沙龙诱导麻醉。气管插管后，将犬连接至输送氧气的麻醉环路。犬被分配接受吸入异氟烷或静脉输注阿法沙龙以维持麻醉。异氟烷最初给药以达到呼气末浓度1.4%，阿法沙龙最初以0.13毫克/千克·分钟的速度给药。在手术过程中调整异氟烷或阿法沙龙的剂量以产生临床上等效的麻醉深度。所有犬均进行机械通气以使二氧化碳分压正常（动脉血二氧化碳分压35 - 40毫米汞柱；4.67 - 5.33千帕）。被动保暖使核心体温维持在37至38摄氏度之间。在基线（麻醉开始后60分钟）以及失血32毫升/千克和48毫升/千克后，测定并计算心血管功能指标，包括平均动脉血压（MAP）、心脏指数（CI）、全身血管阻力指数（SVRI）氧输送指数（D˙O2I）、氧消耗指数（V˙O2I）和氧摄取率（OER）。
在所有犬中，失血导致MAP、CI、D˙O2显著降低，SVRI、V˙O2I和OER显著升高。接受异氟烷的犬和接受阿法沙龙的犬之间，各指标的变化无显著差异。
在失血的灵缇犬麻醉维持中，使用吸入异氟烷或静脉输注阿法沙龙时，未观察到氧输送或休克严重程度的差异。在失血的犬中，选择一种麻醉剂维持麻醉似乎并不比另一种具有临床优势。
Zotero 插件