Wentland Andrew L, Wieben Oliver, Shanmuganayagam Dhanansayan, Krueger Christian G, Meudt Jennifer J, Consigny Daniel, Rivera Leonardo, McBride Patrick E, Reed Jess D, Grist Thomas M
Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
J Magn Reson Imaging. 2015 May;41(5):1475-85. doi: 10.1002/jmri.24681. Epub 2014 Jun 25.
To assess measurements of pulse wave velocity (PWV) and wall shear stress (WSS) in a swine model of atherosclerosis.
Nine familial hypercholesterolemic (FH) swine with angioplasty balloon catheter-induced atherosclerotic lesions to the abdominal aorta (injured group) and 10 uninjured FH swine were evaluated with a 4D phase contrast (PC) magnetic resonance imaging (MRI) acquisition, as well as with radial and Cartesian 2D PC acquisitions, on a 3T MR scanner. PWV values were computed from the 2D and 4D PC techniques, compared between the injured and uninjured swine, and validated against reference standard pressure probe-based PWV measurements. WSS values were also computed from the 4D PC MRI technique and compared between injured and uninjured groups.
PWV values were significantly greater in the injured than in the uninjured groups with the 4D PC MRI technique (P = 0.03) and pressure probes (P = 0.02). No significant differences were found in PWV between groups using the 2D PC techniques (P = 0.75-0.83). No significant differences were found for WSS values between the injured and uninjured groups.
The 4D PC MRI technique provides a promising means of evaluating PWV and WSS in a swine model of atherosclerosis, providing a potential platform for developing the technique for the early detection of atherosclerosis.
评估动脉粥样硬化猪模型中的脉搏波速度（PWV）和壁面切应力（WSS）测量值。
在一台3T磁共振成像（MRI）扫描仪上，对9只经血管成形术球囊导管诱导腹主动脉出现动脉粥样硬化病变的家族性高胆固醇血症（FH）猪（损伤组）和10只未受伤的FH猪进行了四维相位对比（PC）MRI采集，以及径向和笛卡尔二维PC采集。通过二维和四维PC技术计算PWV值，比较损伤猪和未损伤猪之间的差异，并与基于参考标准压力探头的PWV测量值进行验证。WSS值也通过四维PC MRI技术计算，并在损伤组和未损伤组之间进行比较。
使用四维PC MRI技术（P = 0.03）和压力探头（P = 0.02）时，损伤组的PWV值显著高于未损伤组。使用二维PC技术时，两组之间的PWV无显著差异（P = 0.75 - 0.83）。损伤组和未损伤组之间的WSS值无显著差异。
四维PC MRI技术为评估动脉粥样硬化猪模型中的PWV和WSS提供了一种有前景的方法，为开发动脉粥样硬化早期检测技术提供了一个潜在平台。
