病毒和细胞蛋白激酶抑制剂对人巨细胞病毒破坏核纤层和核出芽影响的比较
Comparison of effects of inhibitors of viral and cellular protein kinases on human cytomegalovirus disruption of nuclear lamina and nuclear egress.
作者信息
Sharma Mayuri, Coen Donald M
机构信息
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
出版信息
J Virol. 2014 Sep;88(18):10982-5. doi: 10.1128/JVI.01391-14. Epub 2014 Jun 25.
Abstract
Human cytomegalovirus (HCMV) kinase UL97 is required for efficient nuclear lamina disruption during nuclear egress. However, cellular protein kinase C (PKC) has been implicated in this process in other systems. Comparing the effects of UL97 and cellular kinase inhibitors on HCMV nuclear egress confirms a role for UL97 in lamina disruption and nuclear egress. A pan-PKC inhibitor did not affect lamina disruption but did reduce the number of cytoplasmic capsids more than the number of nuclear capsids.
摘要
人巨细胞病毒（HCMV）激酶UL97是核出芽过程中有效破坏核纤层所必需的。然而，在其他系统中，细胞蛋白激酶C（PKC）也参与了这一过程。比较UL97和细胞激酶抑制剂对HCMV核出芽的影响，证实了UL97在核纤层破坏和核出芽中的作用。一种泛PKC抑制剂并不影响核纤层破坏，但确实使细胞质衣壳的数量比细胞核衣壳的数量减少得更多。
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本文引用的文献
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Inactivation of retinoblastoma protein does not overcome the requirement for human cytomegalovirus UL97 in lamina disruption and nuclear egress.视网膜母细胞瘤蛋白失活并不能克服人巨细胞病毒 UL97 在破坏核膜和核输出中的作用。
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