Medical School of Dicle University, Department of Cardiovascular Surgery, Diyarbakir, Turkey.
Iran J Basic Med Sci. 2014 May;17(5):318-21.
Biochemical markers are important for the timely diagnosis and follow-up of ischemic events. Most of the markers have been previously studied in the context of cardiac ischemia. However, research on markers of non-cardiac events has been insufficient. Therefore, we investigated the relationship between troponin and myoglobin which are commonly used markers of cardiac ischemia, in non-cardiac ischemia.
Forty-eight rats were equally divided into six groups. Group I was the control group. Group II was the sham group and received a simple laparotomy. The superior mesenteric artery was clamped in groups III and IV in order to create mesenteric ischemia. The left femoral artery was clamped in groups V and VI in order to create peripheral ischemia. Intracardiac blood samples were taken from all groups (during the 3(rd) hour of ischemia in groups III and V and the 6(th) hour of ischemia in group IV and VI) and troponin T and myoglobin levels were measured.
Troponin and myoglobin levels were statistically similar in groups I and II. Moreover, increments were detected for troponin and myoglobin in ischemia groups according to group I and II. Furthermore, higher troponin Tlevels were detected after three hours of mesenteric ischemia and higher myoglobin values were observed after six hours of mesenteric ischemia (P<0.05).
Troponin T and myoglobin are not specific for non-cardiac ischemia, and they may be useful for detecting other ischemic events.
生化标志物对于及时诊断和随访缺血性事件非常重要。大多数标志物之前已经在心脏缺血的背景下进行了研究。然而，对非心脏事件标志物的研究还不够充分。因此，我们研究了心肌缺血常用标志物肌钙蛋白和肌红蛋白在非心脏缺血中的关系。
48 只大鼠平均分为六组。I 组为对照组，II 组为假手术组，仅行简单的剖腹术。III 组和 IV 组夹闭肠系膜上动脉以造成肠系膜缺血，V 组和 VI 组夹闭左股动脉以造成外周缺血。所有组均取心血标本（III 组和 V 组于缺血第 3 小时，IV 组和 VI 组于缺血第 6 小时），检测肌钙蛋白 T 和肌红蛋白水平。
I 组和 II 组的肌钙蛋白和肌红蛋白水平无统计学差异。与 I 组和 II 组相比，缺血组的肌钙蛋白和肌红蛋白均有升高。此外，肠系膜缺血 3 小时后肌钙蛋白 T 水平升高，肠系膜缺血 6 小时后肌红蛋白水平升高（P<0.05）。
肌钙蛋白 T 和肌红蛋白对非心脏缺血不具有特异性，它们可能有助于检测其他缺血性事件。
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