自传体叙事与老年人的阿尔茨海默病生物标志物相关。

Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults.

作者信息

Buckley Rachel F, Saling Michael M, Irish Muireann, Ames David, Rowe Christopher C, Villemagne Victor L, Lautenschlager Nicola T, Maruff Paul, Macaulay S Lance, Martins Ralph N, Szoeke Cassandra, Masters Colin L, Rainey-Smith Stephanie R, Rembach Alan, Savage Greg, Ellis Kathryn A

机构信息

Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia.

The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.

出版信息

Int Psychogeriatr. 2014 Oct;26(10):1737-1746. doi: 10.1017/S1041610214001136. Epub 2014 Jun 27.

DOI:10.1017/S1041610214001136

PMID:24969443

Abstract

BACKGROUND

Autobiographical memory (ABM), personal semantic memory (PSM), and autonoetic consciousness are affected in individuals with mild cognitive impairment (MCI) but their relationship with Alzheimer's disease (AD) biomarkers are unclear.

METHODS

Forty-five participants (healthy controls (HC) = 31, MCI = 14) completed the Episodic ABM Interview and a battery of memory tests. Thirty-one (HC = 22, MCI = 9) underwent β-amyloid positron emission tomography (PET) and magnetic resonance (MR) imaging. Fourteen participants (HC = 9, MCI = 5) underwent one imaging modality.

RESULTS

Unlike PSM, ABM differentiated between diagnostic categories but did not relate to AD biomarkers. Personal semantic memory was related to neocortical β-amyloid burden after adjusting for age and apolipoprotein E (APOE) ɛ4. Autonoetic consciousness was not associated with AD biomarkers, and was not impaired in MCI.

CONCLUSIONS

Autobiographical memory was impaired in MCI participants but was not related to neocortical amyloid burden, suggesting that personal memory systems are impacted by differing disease mechanisms, rather than being uniformly underpinned by β-amyloid. Episodic and semantic ABM impairment represent an important AD prodrome.

摘要