Altundag Aytug, Salihoglu Murat, Cayonu Melih, Cingi Cemal, Tekeli Hakan, Hummel Thomas
Division of Otorhinolaryngology, Istanbul Surgery Hospital, Ferah Sok. No: 22 Şişli, Istanbul, 34365, Turkey,
Eur Arch Otorhinolaryngol. 2014 Sep;271(9):2583-6. doi: 10.1007/s00405-014-3170-8. Epub 2014 Jun 28.
The aim of the present study was to investigate whether nasal nitric oxide (nNO) levels change in relation to high altitude in a natural setting where the weather conditions were favorable. The present study included 41 healthy volunteers without a history of acute rhinosinusitis within 3 weeks and nasal polyposis. The study group consisted of 31 males (76 %) and 10 females (24 %) and the mean age of the study population was 38 ± 10 years. The volunteers encamped for 2 days in a mountain village at an altitude of 1,500 m above sea level (masl) and proceeded to highlands at an altitude of 2,200 masl throughout the day. The measurements of nNO were done randomly, either first at the mountain village or at sea level. Each participant had nNO values both at sea level and at high altitude at the end of the study. The nNO values of sea level and high altitude were compared to investigate the effect of high altitude on nNO levels. The mean of average nNO measurements at the high altitude was 74.2 ± 41 parts-per-billion (ppb) and the mean of the measurements at sea level was 93.4 ± 45 ppb. The change in nNO depending on the altitude level was statistically significant (p < 0.001). The current investigation showed that nNO levels were decreased at high altitude even if the weather conditions were favorable, such as temperature, humidity, and wind.
本研究的目的是在天气条件适宜的自然环境中，调查鼻一氧化氮（nNO）水平是否会随着海拔高度的变化而改变。本研究纳入了41名健康志愿者，他们在3周内无急性鼻窦炎病史且无鼻息肉。研究组由31名男性（76%）和10名女性（24%）组成，研究人群的平均年龄为38±10岁。志愿者们在海拔1500米的山村露营2天，然后全天前往海拔2200米的高地。nNO的测量是随机进行的，要么首先在山村进行，要么在海平面进行。在研究结束时，每位参与者在海平面和高海拔处都有nNO值。比较海平面和高海拔处的nNO值，以研究高海拔对nNO水平的影响。高海拔处平均nNO测量值的平均值为74.2±41十亿分之一（ppb），海平面测量值的平均值为93.4±45 ppb。nNO随海拔高度的变化具有统计学意义（p<0.001）。当前的调查表明，即使温度、湿度和风等天气条件适宜，高海拔处的nNO水平也会降低。
