Geurden T, Slootmans N, Glover M, Bartram D J
Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20, 1930 Zaventem, Belgium.
Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20, 1930 Zaventem, Belgium.
Vet Parasitol. 2014 Sep 15;205(1-2):405-7. doi: 10.1016/j.vetpar.2014.06.012. Epub 2014 Jun 17.
Gastrointestinal nematodes have a negative impact on the productivity of grazing sheep. Control of these infections has relied for decades on the use of anthelminics, leading to anthelmintic resistance (AR) worldwide, including the UK. The use of combination anthelmintics has been advocated as one of the tools in managing AR and decreasing the economic losses associated with AR. In this study, the benefit of a new combination (derquantel plus abamectin; DQL+ABA: Startect(®) Dual Active Oral Solution for Sheep, Zoetis, at 1 mL/5 kg bodyweight) was evaluated on a farm with suspected AR to benzimidazoles, by incorporating it into the existing treatment regime. In total 100 lambs were selected and allocated to one of two treatment groups, which were treated either with DQL+ABA or fenbendazole/levamisole at monthly intervals. All lambs were co-grazing the same pasture. Weight gain and carcass quality was evaluated, as well as treatment efficacy. The efficacy of DQL+ABA was high throughout the grazing season, whereas the efficacy of the fenbendazole/levamisole treatment regime was below the threshold for anthelmintic efficacy. The high efficacy of a monthly treatment with DQL+ABA resulted in a significantly higher average daily weight gain and shorter time to reach slaughter.
胃肠道线虫对放牧绵羊的生产力有负面影响。数十年来，对这些感染的控制一直依赖于使用驱虫药，这导致了包括英国在内的全球范围内的驱虫药抗性（AR）。提倡使用复方驱虫药作为管理驱虫药抗性和减少与驱虫药抗性相关的经济损失的工具之一。在本研究中，通过将一种新的复方制剂（地克珠利加阿维菌素；DQL+ABA：适用于绵羊的Startect®双效口服溶液，硕腾公司，按每5千克体重1毫升给药）纳入现有的治疗方案，在一个怀疑对苯并咪唑类药物有抗性的农场中评估了其效果。总共挑选了100只羔羊，并将其分配到两个治疗组之一，两组分别每月用DQL+ABA或芬苯达唑/左旋咪唑进行治疗。所有羔羊共同在同一牧场放牧。评估了体重增加、胴体质量以及治疗效果。在整个放牧季节，DQL+ABA的疗效都很高，而芬苯达唑/左旋咪唑治疗方案的疗效低于驱虫药疗效阈值。每月使用DQL+ABA进行治疗的高效性导致平均日增重显著更高，且达到屠宰体重的时间更短。
