泛素化和类泛素化修饰在糖尿病肾病中的作用
The role of ubiquitination and sumoylation in diabetic nephropathy.
作者信息
Gao Chenlin, Huang Wei, Kanasaki Keizo, Xu Yong
机构信息
Department of Endocrinology, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, China.
Division of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan.
出版信息
Biomed Res Int. 2014;2014:160692. doi: 10.1155/2014/160692. Epub 2014 Jun 4.
Diabetic nephropathy (DN) is a common and characteristic microvascular complication of diabetes; the mechanisms that cause DN have not been clarified, and the epigenetic mechanism was promised in the pathology of DN. Furthermore, ubiquitination and small ubiquitin-like modifier (SUMO) were involved in the progression of DN. MG132, as a ubiquitin proteasome, could improve renal injury by regulating several signaling pathways, such as NF- κ B, TGF- β , Nrf2-oxidative stress, and MAPK. In this review, we summarize how ubiquitination and sumoylation may contribute to the pathology of DN, which may be a potential treatment strategy of DN.
糖尿病肾病（DN）是糖尿病常见且具有特征性的微血管并发症；导致DN的机制尚未阐明，表观遗传机制在DN病理学中被寄予厚望。此外，泛素化和类泛素化修饰（SUMO）参与了DN的进展。MG132作为一种泛素蛋白酶体，可通过调节多种信号通路，如核因子κB（NF-κB）、转化生长因子β（TGF-β）、核因子E2相关因子2-氧化应激（Nrf2-oxidative stress）和丝裂原活化蛋白激酶（MAPK），来改善肾损伤。在本综述中，我们总结了泛素化和类泛素化修饰如何可能导致DN的病理过程，这可能是DN的一种潜在治疗策略。
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