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老年人社会功能与前额叶血流动力学反应之间的关联。

Association between social functioning and prefrontal hemodynamic responses in elderly adults.

作者信息

Pu Shenghong, Nakagome Kazuyuki, Yamada Takeshi, Yokoyama Katsutoshi, Matsumura Hiroshi, Mitani Hideaki, Adachi Akiko, Kaneko Koichi

机构信息

Division of Neuropsychiatry, Department of Brain and Neuroscience, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, Tottori 683-8504, Japan.

National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan.

出版信息

Behav Brain Res. 2014 Oct 1;272:32-9. doi: 10.1016/j.bbr.2014.06.052. Epub 2014 Jun 30.

Abstract

Social functioning has received widespread attention as one of the most important outcomes in psychiatric disorders and has been related to cognitive functioning and the underlying brain activity. Cognitive decline, however, appears not only in the psychiatric population but also in aged individuals. In our previous study, we demonstrated a significant relationship between social functioning and prefrontal cortex (PFC) activity in patients with depression. However, it has not been shown whether the above relationship could be extended to healthy populations. The purpose of the present study was to investigate a possible association between social functioning and prefrontal hemodynamic responses in healthy elderly adults by using a non-invasive and low-constraint functional neuroimaging technique, near-infrared spectroscopy (NIRS). Study subjects included 55 healthy, elderly volunteers. We measured hemodynamic responses over prefrontal cortical (PFC) areas during the verbal fluency task by using multi-channel NIRS and analyzed the relationship between task-associated hemodynamic responses and social functioning as measured by the social adaptation self-evaluation scale (SASS). A significant positive relationship was observed between the SASS total score and PFC activation. Our findings suggest that PFC activation is associated with social functioning in healthy elderly adults. Furthermore, hemodynamic responses assessed using non-invasive NIRS could be a useful biological marker of these characteristics.

摘要

社会功能作为精神疾病最重要的预后指标之一受到广泛关注,并且与认知功能及潜在的大脑活动相关。然而,认知衰退不仅出现在精神疾病患者中,也出现在老年人中。在我们之前的研究中,我们证明了抑郁症患者的社会功能与前额叶皮质(PFC)活动之间存在显著关系。然而,上述关系是否能扩展到健康人群尚未得到证实。本研究的目的是通过使用非侵入性且限制较小的功能性神经成像技术——近红外光谱(NIRS),研究健康老年人的社会功能与前额叶血流动力学反应之间可能存在的关联。研究对象包括55名健康的老年志愿者。我们使用多通道NIRS在言语流畅性任务期间测量前额叶皮质(PFC)区域的血流动力学反应,并分析任务相关血流动力学反应与社会适应自我评估量表(SASS)所测量的社会功能之间的关系。观察到SASS总分与PFC激活之间存在显著正相关。我们的研究结果表明,PFC激活与健康老年人的社会功能相关。此外,使用非侵入性NIRS评估的血流动力学反应可能是这些特征的有用生物学标志物。

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