由协同的（氮杂环卡宾）-铜和-钯配合物催化的Sonogashira偶联反应。
Sonogashira couplings catalyzed by collaborative (N-heterocyclic carbene)-copper and -palladium complexes.
作者信息
Gallop Christopher W D, Chen Ming-Tsz, Navarro Oscar
机构信息
Department of Chemistry, University of Sussex , Brighton BN1 9QJ, United Kingdom.
出版信息
Org Lett. 2014 Jul 18;16(14):3724-7. doi: 10.1021/ol501540w. Epub 2014 Jul 3.
PMID:24992380
Abstract
A general protocol for the Sonogashira reaction using a 100:1 combination of (N-heterocyclic carbene)-Cu and (N-heterocyclic carbene)-Pd complexes is presented. Catalyst loadings of 1 mol % (NHC)-Cu and 0.01 mol % (NHC)-Pd allow for the coupling of aryl bromides and aryl alkynes, in air and in a non-anhydrous solvent, in high yields.
摘要
本文介绍了一种使用（N-杂环卡宾）-铜和（N-杂环卡宾）-钯配合物100:1组合的Sonogashira反应通用方案。1 mol%（NHC）-铜和0.01 mol%（NHC）-钯的催化剂负载量可使芳基溴化物和芳基炔烃在空气中以及非无水溶剂中高产率地偶联。
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