对土耳其库库洛瓦地区2150例围产期尸检进行的尸检评估。
Perinatal autopsy evaluation of 2150 autopsies in the Çukurova region of Turkey.
作者信息
Açikalin Arbil, Bağir Emine Kiliç, Torun Goncagül, Ateş Berna Totan, Erdoğan Seyda, Uğuz Aysun, Ergın Melek, Büyükkurt Selim, Ozgünen Fatma Tuncay, Tunali Nurdan, Gümürdülü Derya
机构信息
Department of Pathology, Çukurova University, Faculty of Medicine, ADANA, TURKEY.
出版信息
Turk Patoloji Derg. 2014;30(3):189-94. doi: 10.5146/tjpath.2014.01266.
OBJECTIVE
We aimed to document the reasons of perinatal deaths in a large autopsy series performed in our institute, which is a reference center in the Çukurova region of Turkey.
MATERIAL AND METHOD
The study included 2150 autopsies performed between January 2000 and December 2012 at our institute. Diagnoses were categorized according to the detected pathologies; congenital malformations were detailed based on systems.
RESULTS
A pathology was detected in 1619 of 2150 (73.3%) autopsies. Congenital malformations were the most common diagnosis with 68.2%. Neural tube defects and central nervous system malformations were the most frequent system malformation in 28.8% of cases, followed by the urogenital system (11.4%) and musculoskeletal system (8.3%), respectively. Malformation syndromes including multisystem anomalies were defined in 109 cases (9.3%).
CONCLUSION
Congenital malformations are the most common reason for perinatal deaths, with autopsy having an additive role to prenatal and genetic evaluations and providing foresight for planning a subsequent pregnancy.
目的
我们旨在记录在我院进行的大量尸检系列中围产期死亡的原因，我院是土耳其丘库罗瓦地区的一个参考中心。
材料与方法
该研究纳入了2000年1月至2012年12月在我院进行的2150例尸检。诊断根据检测到的病理情况进行分类；先天性畸形根据系统进行详细分类。
结果
在2150例尸检中，有1619例（73.3%）检测到病理情况。先天性畸形是最常见的诊断，占68.2%。神经管缺陷和中枢神经系统畸形是最常见的系统畸形，分别占28.8%的病例，其次是泌尿生殖系统（11.4%）和肌肉骨骼系统（8.3%）。109例（9.3%）病例定义了包括多系统异常的畸形综合征。
结论
先天性畸形是围产期死亡的最常见原因，尸检对产前和基因评估具有补充作用，并为后续妊娠计划提供前瞻性指导。
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