Gressot Loyola V, Chamoun Roukoz B, Patel Akash J, Valadka Alex B, Suki Dima, Robertson Claudia S, Gopinath Shankar P
Department of Neurosurgery, Baylor College of Medicine, Houston, Texas;
J Neurosurg. 2014 Sep;121(3):645-52. doi: 10.3171/2014.5.JNS131872. Epub 2014 Jul 4.
Prediction of outcome from initial presentation after a gunshot wound to the head (GSWH) is essential to further clinical decision making. The authors' goals are to report the survival and functional outcomes of these patients, to identify prognostic factors, and to propose a scoring system that can predict their outcome.
The records of 199 patients admitted with a GSWH with dural penetration between 1990 and 2008 were retrospectively reviewed. The inclusion criterion was a CT scan available for review. Patients declared brain dead on presentation were excluded, which yielded a series of 119 patients. Statistical analysis was performed using a logistic regression model.
Fifty-eight (49%) of the 119 patients died. Twenty-three patients (19%) had a favorable outcome defined as a 6-month Glasgow Outcome Scale (GOS) score of moderate disability or good recovery, 35 (29%) had a poor outcome (GOS of persistent vegetative state or severe disability), and 3 (3%) were lost to follow-up. Significant prognostic factors for mortality were age older than 35 years, nonreactive pupils, bullet trajectory of bihemispheric (excluding bifrontal), and posterior fossa involvement compared with unihemispheric and bifrontal. Factors that were moderately associated with higher mortality included intracranial pressure (ICP) above 20 mm Hg and Glasgow Coma Scale (GCS) score at presentation of 3 or 4. Upon multivariate analysis, the significant factors for mortality were bullet trajectory and pupillary response. Variables found to be significant for good functional outcome were admission GCS score greater than or equal to 5, pupillary reactivity, and bullet trajectory of unihemispheric or bifrontal. Factors moderately associated with good outcome included age of 35 years or younger, initial ICP 20 mm Hg or lower, and lack of transventricular trajectory. In the multivariate analysis, significant factors for good functional outcome were bullet trajectory and pupillary response, with age moderately associated with improved functional outcomes. The authors also propose a scoring system to estimate survival and functional outcome.
Age, pupils, GCS score, and bullet trajectory on CT scan can be used to determine likelihood of survival and good functional outcome. The authors advocate assessing patients based on these parameters rather than pronouncing a poor prognosis and withholding aggressive resuscitation based upon low GCS score alone.
预测头部枪伤(GSWH)初始表现后的预后对于进一步的临床决策至关重要。作者的目标是报告这些患者的生存和功能结局,确定预后因素,并提出一种能够预测其结局的评分系统。
对1990年至2008年间收治的199例硬脑膜穿透性GSWH患者的记录进行回顾性分析。纳入标准是有可供复查的CT扫描。排除入院时宣布脑死亡的患者,最终得到119例患者。使用逻辑回归模型进行统计分析。
119例患者中有58例(49%)死亡。23例患者(19%)预后良好,定义为格拉斯哥预后量表(GOS)6个月评分为中度残疾或恢复良好;35例(29%)预后不良(GOS为持续性植物状态或严重残疾);3例(3%)失访。死亡的显著预后因素包括年龄大于35岁、瞳孔无反应、双半球(不包括双额叶)的子弹轨迹以及与单半球和双额叶相比的后颅窝受累。与较高死亡率中度相关的因素包括颅内压(ICP)高于20 mmHg以及入院时格拉斯哥昏迷量表(GCS)评分为3或4分。多因素分析显示,死亡的显著因素是子弹轨迹和瞳孔反应。发现对良好功能结局有显著意义的变量包括入院时GCS评分大于或等于5分、瞳孔反应性以及单半球或双额叶的子弹轨迹。与良好结局中度相关的因素包括年龄35岁或以下、初始ICP 20 mmHg或更低以及无经脑室轨迹。多因素分析中,良好功能结局的显著因素是子弹轨迹和瞳孔反应,年龄与功能结局改善中度相关。作者还提出了一种评分系统来估计生存和功能结局。
年龄、瞳孔、GCS评分以及CT扫描上的子弹轨迹可用于确定生存可能性和良好功能结局。作者主张基于这些参数评估患者,而不是仅根据低GCS评分就判定预后不良并放弃积极复苏。