Unité de neurosciences cellulaires et moléculaire, Institut universitaire en santé mentale de Québec, Québec, Canada.
1] Unité de neurosciences cellulaires et moléculaire, Institut universitaire en santé mentale de Québec, Québec, Canada. [2] Department of Psychiatry and Neuroscience, Université Laval, Québec, Canada.
Nat Neurosci. 2014 Aug;17(8):1043-5. doi: 10.1038/nn.3758. Epub 2014 Jul 6.
Hyperalgesia arising from sensitization of pain relays in the spinal dorsal horn shares many mechanistic and phenotypic parallels with memory formation. We discovered that mechanical hyperalgesia could be rendered labile and reversible in mice after reactivation of spinal pain pathways in a process analogous to memory reconsolidation. These findings reveal a previously unknown regulatory mechanism underlying hyperalgesia and demonstrate the existence of reconsolidation-like processes in a sensory system.
痛觉中继敏感化引起的痛觉过敏与记忆形成在机制和表型上有许多相似之处。我们发现，在类似于记忆再巩固的过程中，重新激活脊髓疼痛通路后，小鼠的机械性痛觉过敏可以变得不稳定和可逆。这些发现揭示了痛觉过敏的一个以前未知的调节机制，并证明了在感觉系统中存在类似于再巩固的过程。
