Cun Lingli, Wang Yanqiu, Zhang Songyan, Wei Dongtao, Qiu Jiang
aKey Laboratory of Cognition and Personality (SWU), Ministry of Education bDepartment of Psychology, Southwest University, Chongqing, China.
Neuroreport. 2014 Sep 10;25(13):1030-7. doi: 10.1097/WNR.0000000000000222.
Negative automatic thought is a characteristic of depression that contributes toward the risk for episodes of depression. Evidence suggests that gray and white matter abnormalities are linked with depression, but little is known about the association between the negative cognitive experience and brain structure in preclinical depression. We examined the correlation between negative thought and gray (GMV)/white matter volume (WMV) in healthy individuals with preclinical depression. The participants were 309 university students with preclinical depression, as measured by their Automatic Thoughts Questionnaire (ATQ) scores. We collected brain MRIs and used voxel-based morphometry to analyze the correlation of regional GMV/WMV with the ATQ scores. The voxel-based morphometry results showed that the GMV of the right parahippocampal gyrus and fusiform gyrus and the WMV of the right superior temporal pole increased with the severity of depression. Furthermore, the corpus callosum volume decreased with the ATQ scores. This study implied that GMV increase and corpus callosum volume reduction may be associated with negative thought in nonclinical individuals, even at a preclinical depressed level.
消极自动思维是抑郁症的一个特征，它会增加抑郁症发作的风险。有证据表明，灰质和白质异常与抑郁症有关，但在临床前抑郁症中，关于消极认知体验与脑结构之间的关联却知之甚少。我们研究了临床前抑郁症的健康个体中消极思维与灰质体积（GMV）/白质体积（WMV）之间的相关性。参与者为309名大学生，通过他们的自动思维问卷（ATQ）得分来衡量其处于临床前抑郁状态。我们收集了脑部MRI图像，并使用基于体素的形态测量法来分析区域GMV/WMV与ATQ得分之间的相关性。基于体素的形态测量结果显示，右侧海马旁回和梭状回的GMV以及右侧颞上极的WMV随着抑郁严重程度的增加而增加。此外，胼胝体体积随ATQ得分降低。这项研究表明，即使在临床前抑郁水平，GMV增加和胼胝体体积减小可能与非临床个体的消极思维有关。
