下尿路的神经控制及药物治疗靶点

Neural control of lower urinary tract and targets for pharmacological therapy.

作者信息

Bortolini Maria Augusta T, Bilhar Andreisa P M, Castro Rodrigo A

机构信息

Sector of Urogynecology and Vaginal Surgery, Department of Gynecology, Federal University of São Paulo, Rua Rodolfo Belz, 220/42A, São Paulo, 05639-010, SP, Brazil,

出版信息

Int Urogynecol J. 2014 Nov;25(11):1453-62. doi: 10.1007/s00192-014-2452-4. Epub 2014 Jul 8.

DOI:10.1007/s00192-014-2452-4

PMID:25001574

Abstract

Studies on the physiology and pharmacology of the lower urinary tract have brought new information and concepts about the complex neural control of micturition. There are many mechanisms, some proven and others not yet completely understood, in which pharmacological agents may act facilitating the filling, storage, and emptying of the bladder. This review describes the peripheral innervation and the main pathways involved in lower urinary tract control. It also presents potential targets for the treatment of voiding dysfunctions.

摘要

对下尿路生理和药理学的研究带来了关于排尿复杂神经控制的新信息和概念。在促进膀胱充盈、储存和排空方面，药物可能通过多种机制起作用，其中一些机制已得到证实，另一些尚未完全明了。本综述描述了下尿路控制所涉及的外周神经支配和主要途径。它还提出了治疗排尿功能障碍的潜在靶点。