一项关于红曲米、水飞蓟素和 octasonol 营养组合对血脂谱、内皮和炎症参数影响的随机、安慰剂对照研究。
A randomized, placebo-controlled study on the effects of a nutraceutical combination of red yeast rice, silybum marianum and octasonol on lipid profile, endothelial and inflammatory parameters.
机构信息
Department of Internal Medicine and Therapeutics, University of Pavia, and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.
出版信息
J Biol Regul Homeost Agents. 2014 Apr-Jun;28(2):317-24.
The aim of this study was to evaluate the effects of a combination of red yeast rice, Silybum marianum and octasonol compared to placebo on lipid profile, endothelial, and inflammatory parameters in low risk dislipidemic patients. One hundred and thirty-four dislipidemic patients were randomised to take placebo or a patented nutraceutical association in tablet form (Zeta ColestRT), 1 tablet /day (immediately after the dinner), for three months in a double-blind, placebo-controlled trial. At baseline and after 3 months the following were evaluated: body weight, body mass index (BMI), fasting plasma glucose (FPG), lipid profile, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin (sE-selectin), metalloprotineases-2 and -9 (MMP-2 and MMP-9), high sensitivity C-reactive protein (Hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha). The nutraceutical combination decreased total cholesterol and low density lipoprotein cholesterol compared to baseline (p = 0.042, and p = 0.041, respectively) and to placebo (p = 0.039, and p = 0.037, respectively). Triglycerides were reduced by the active treatment (p = 0.039), but not by placebo, even if, in group to group comparison, no differences were recorded (p = 0.061). All adipocytokines were reduced by the nutraceutical combination, in particular p = 0.044 for sICAM-1, p = 0.045 for sVCAM-1, p = 0.040 for sE-selectin, p = 0.035 for MMP-2, p = 0.039 for MMP-9, p = 0.038 for Hs-CRP, p = 0.036 for TNF-α, and p = 0.036 for IL-6 compared to baseline, and p = 0.042 for sICAM-1, p = 0.043 for sVCAM-1, p = 0.042 for sE-selectin, p = 0.031 for MMP-2, p = 0.038 for MMP-9, p =0.038 for Hs-CRP, and p = 0.043 for TNF-alpha, espectively, compared to placebo. We can conclude that a combination of red yeast rice, Silybum marianum and octasonol was effective in improving lipid profile, endothelial, and inflammatory parameters in low risk dislipidemic patients.
本研究旨在评估红曲米、水飞蓟素和八角素组合与安慰剂相比，对低危血脂异常患者的血脂谱、内皮和炎症参数的影响。134 名血脂异常患者被随机分配服用安慰剂或专利营养保健品（Zeta ColestRT），每天 1 片（晚饭后立即服用），进行为期 3 个月的双盲、安慰剂对照试验。在基线和 3 个月后评估以下参数：体重、体重指数（BMI）、空腹血糖（FPG）、血脂谱、可溶性细胞间黏附分子-1（sICAM-1）、可溶性血管细胞黏附分子-1（sVCAM-1）、可溶性 E-选择素（sE-selectin）、金属蛋白酶-2 和 -9（MMP-2 和 MMP-9）、高敏 C 反应蛋白（Hs-CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）。营养保健品组合可降低总胆固醇和低密度脂蛋白胆固醇，与基线相比（p=0.042 和 p=0.041）和安慰剂相比（p=0.039 和 p=0.037）。活性治疗可降低甘油三酯（p=0.039），但安慰剂组无此作用，尽管组间比较无差异（p=0.061）。营养保健品组合可降低所有脂肪细胞因子，特别是 sICAM-1 降低 0.044（p=0.044），sVCAM-1 降低 0.045（p=0.045），sE-selectin 降低 0.040（p=0.040），MMP-2 降低 0.035（p=0.035），MMP-9 降低 0.039（p=0.039），Hs-CRP 降低 0.038（p=0.038），TNF-α降低 0.036（p=0.036），与基线相比，sICAM-1 降低 0.042（p=0.042），sVCAM-1 降低 0.043（p=0.043），sE-selectin 降低 0.042（p=0.042），MMP-2 降低 0.031（p=0.031），MMP-9 降低 0.038（p=0.038），Hs-CRP 降低 0.038（p=0.038），TNF-α降低 0.043（p=0.043）。我们可以得出结论，红曲米、水飞蓟素和八角素的组合在改善低危血脂异常患者的血脂谱、内皮和炎症参数方面是有效的。
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