小儿急性白血病中的后部可逆性脑病综合征：病例系列及文献综述

Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review.

作者信息

Appachu M Sandhya, Purohit Samit, Lakshmaiah K C, Kumari B S Aruna, Appaji L

机构信息

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India.

Department of Pediatric Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India.

出版信息

Indian J Med Paediatr Oncol. 2014 Jan;35(1):79-82. doi: 10.4103/0971-5851.133727.

DOI:10.4103/0971-5851.133727

PMID:25006290

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4080669/

Abstract

Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state coupled with a unique radio imaging appearance. We describe this rare, mostly reversible condition in five cases undergoing similar treatment under preset protocol (MCP-841) for acute lymphoblastic leukemia (ALL) at our centre. Hypertension is a well-known adverse effect of high-dose corticosteroid therapy primarily mediated by its effects on the mineralocorticoid receptor especially in pediatric population and we hypothesize that this may be the etiology of PRES in two of these patients.

摘要

后部可逆性脑病综合征（PRES）是一种伴有独特影像学表现的神经毒性状态。我们描述了在我们中心接受针对急性淋巴细胞白血病（ALL）的预设方案（MCP - 841）进行类似治疗的5例患者中出现的这种罕见且大多可逆的病症。高血压是高剂量糖皮质激素治疗的一种众所周知的不良反应，主要通过其对盐皮质激素受体的作用介导，尤其是在儿科人群中，我们推测这可能是其中2例患者发生PRES的病因。