快速致盲性后结核性葡萄膜炎
Rapidly blinding posterior tubercular uveitis.
作者信息
Agarwal Manisha, Jha Vivek, Biswas Jyotirmay
机构信息
Vitreoretina Services, Dr. Shroff's Charity Eye Hospital, 5027-Kedar Nath Road, Daryaganj, New Delhi 110002, India.
Internal Medicine Services, Dr. Shroff's Charity Eye Hospital, 5027-Kedar Nath Road, Daryaganj, New Delhi 110002, India.
出版信息
J Ophthalmic Inflamm Infect. 2014 Jun 9;4:13. doi: 10.1186/1869-5760-4-13. eCollection 2014.
BACKGROUND
A 21-year-old female patient had chorioretinitis in the left eye which relapsed while being on anti-tubercular treatment and oral corticosteroids leading to blindness and the loss of the left eye.
FINDINGS
Mycobacterium tuberculosis causing chorioretinitis showed a poor response, and the lung lesions showed a good response to the same anti-tubercular treatment.
CONCLUSIONS
Mycobacterium tubercle bacilli in the eye may show a poor response to the anti-tubercular drugs due to poor ocular penetration of the drugs secondary to early ocular hypoxia.
背景
一名21岁女性患者左眼患有脉络膜视网膜炎，在接受抗结核治疗和口服皮质类固醇期间病情复发，导致失明并丧失左眼。
研究结果
引起脉络膜视网膜炎的结核分枝杆菌对抗结核治疗反应不佳，而肺部病变对相同的抗结核治疗反应良好。
结论
由于早期眼部缺氧导致药物眼部穿透性差，眼部的结核杆菌可能对抗结核药物反应不佳。
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