一种新型的VHDJH至JH连接，可在Ig缺陷的未成熟B细胞系中诱导重链产生。
A novel VHDJH to JH joining that induces H chain production in an Ig-null immature B cell line.
作者信息
Komori T, Sugiyama H, Kishimoto S
机构信息
Third Department of Internal Medicine, Osaka University Medical School, Japan.
出版信息
J Immunol. 1989 Aug 1;143(3):1040-5.
A novel Ig H chain gene rearrangement, a VHDJH to JH joining, was observed in an Ig-null immature B cell line. The preexisting, nonproductive VHDJH complex was replaced by the productive VHJH complex which was generated by the novel joining between the rearranged VH and a germ line JH gene. This VHDJH to JH joining is thought to be a site-specific recombinational event mediated by a putative recombination signal sequence, CACAGCC-12-base-GCAAGAAAG, embedded in the rearranged VH gene including the N region. This sequence might be a novel recombination signal sequence, which had not yet been reported, for so-called recombinase.
在一个无免疫球蛋白的未成熟B细胞系中观察到一种新的免疫球蛋白重链基因重排，即VHDJH与JH连接。预先存在的无功能VHDJH复合体被有功能的VHJH复合体所取代，后者是由重排的VH与种系JH基因之间的新连接产生的。这种VHDJH与JH的连接被认为是由一个假定的重组信号序列介导的位点特异性重组事件，该信号序列为CACAGCC-间隔12个碱基-GCAAGAAAG，嵌入包括N区的重排VH基因中。该序列可能是一种尚未被报道的、针对所谓重组酶的新型重组信号序列。
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