Tyagi Prateek, Chandra Sulekh, Saraswat B S
Department of Chemistry, Zakir Husain Delhi College, University of Delhi, JLN-Marg, New Delhi 110002, India; Department of Chemistry, School of Sciences, IGNOU, Maidan Garhi, New Delhi 110068, India.
Department of Chemistry, Zakir Husain Delhi College, University of Delhi, JLN-Marg, New Delhi 110002, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jan 5;134:200-9. doi: 10.1016/j.saa.2014.06.112. Epub 2014 Jun 28.
The paper presents the synthesis of Ni(II) and Zn(II) complexes of general composition M(L)X₂ and M(L)₂X₂ (M=Ni(II), Zn(II), X=Cl(-1), OAc(-1)) with Schiff base obtained through the condensation of 2-aminobenzamide with thiophene-2-carbaldehyde. The characterization of newly formed complexes was done by (1)H NMR, UV-VIS, TGA, IR, mass spectrophotometry and molar conductivity studies. The thermal studies suggested that the complexes are more stable as compared to ligand. In DFT studies the geometries of Schiff's base and metal complexes were fully optimized with respect to the energy using the 6-31+g(d,p) basis set. On the basis of the spectral studies a distorted octahedral geometry has been assigned for Ni(II) complexes and tetrahedral geometry for Zn(II) complexes. The effect of these complexes on proliferation of human breast cancer cell line (MCF-7) and human hepatocellular liver carcinoma cell line (HepG2) were studied and compared with those of free ligand.
本文介绍了通过2-氨基苯甲酰胺与噻吩-2-甲醛缩合得到的席夫碱与通式为M(L)X₂和M(L)₂X₂（M = Ni(II)、Zn(II)，X = Cl⁻、OAc⁻）的镍(II)和锌(II)配合物的合成。通过¹H NMR、UV-VIS、TGA、IR、质谱分析和摩尔电导率研究对新形成的配合物进行了表征。热学研究表明，与配体相比，配合物更稳定。在密度泛函理论（DFT）研究中，使用6-31+g(d,p)基组对席夫碱和金属配合物的几何结构进行了能量方面的完全优化。基于光谱研究，已确定Ni(II)配合物为扭曲八面体几何结构，Zn(II)配合物为四面体几何结构。研究了这些配合物对人乳腺癌细胞系（MCF-7）和人肝癌细胞系（HepG2）增殖的影响，并与游离配体的影响进行了比较。
