Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University Shanghai, China.
Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University Shanghai, China ; Key Laboratory of Parasite and Vector Biology of Ministry of Health, National Institute of Parasitic Diseases, Chinese Center for Diseases Control and Prevention Shanghai, China.
Front Microbiol. 2014 Jun 26;5:313. doi: 10.3389/fmicb.2014.00313. eCollection 2014.
Schistosomiasis, caused by dioecious flatworms in the genus Schistosoma, is torturing people from many developing countries nowadays and frequently leads to severe morbidity and mortality of the patients. Praziquantel based chemotherapy and morbidity control for this disease adopted currently necessitate viable and efficient diagnostic technologies. Fortunately, those "-omics" researches, which rely on high-throughput experimental technologies to produce massive amounts of informative data, have substantially contributed to the exploitation and innovation of diagnostic tools of schistosomiasis. In its first section, this review provides a concise conclusion on the progresses pertaining to schistosomal "-omics" researches to date, followed by a comprehensive section on the diagnostic methods of schistosomiasis, especially those innovative ones based on the detection of antibodies, antigens, nucleic acids, and metabolites with a focus on those achievements inspired by "-omics" researches. Finally, suggestions about the design of future diagnostic tools of schistosomiasis are proposed, in order to better harness those data produced by "-omics" studies.
血吸虫病是由雌雄同体的血吸虫属扁形动物引起的，目前正在折磨着许多发展中国家的人民，经常导致患者严重的发病率和死亡率。目前，基于吡喹酮的化疗和疾病控制需要可行和有效的诊断技术。幸运的是，那些依赖高通量实验技术产生大量信息数据的“组学”研究，极大地促进了血吸虫病诊断工具的开发和创新。在第一部分中，本文简要总结了迄今为止与血吸虫“组学”研究相关的进展，然后全面介绍了血吸虫病的诊断方法，特别是那些基于抗体、抗原、核酸和代谢物检测的创新方法，并重点介绍了受“组学”研究启发的新方法。最后，提出了未来血吸虫病诊断工具设计的建议，以便更好地利用“组学”研究产生的数据。
