University Hospital Southampton, Tremona Road, Hampshire SO16 6YD, UK.
Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7235, USA.
Nat Rev Urol. 2014 Aug;11(8):437-44. doi: 10.1038/nrurol.2014.164. Epub 2014 Jul 15.
Radical cystectomy is associated with high rates of surgical morbidity. The magnitude of the surgical insult is associated with the degree of stress response, particularly in ageing patients with multiple comorbidities. Attempts to limit this response and identify areas of improvement with respect to patient selection and optimization, anaesthesia, surgical technique and postoperative care underpin the multimodal approach to enhanced recovery pathways. No single intervention significantly reduces morbidity, but the combination of many interventions at all levels of the pathway is likely to accelerate the patient journey from diagnosis to return to normal function.
根治性膀胱切除术与较高的手术发病率有关。手术创伤的程度与应激反应的程度有关,特别是在患有多种合并症的老年患者中。为了限制这种反应,并确定在患者选择和优化、麻醉、手术技术和术后护理方面可以改进的领域,以支持强化康复途径的多模式方法。没有单一的干预措施能显著降低发病率,但在途径的所有层面上结合许多干预措施,可能会加速患者从诊断到恢复正常功能的旅程。