胃蛋白酶原 II 可作为 H. pylori 根除前后胃体形态变化的潜在替代标志物。
Pepsinogen II can be a potential surrogate marker of morphological changes in corpus before and after H. pylori eradication.
机构信息
Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran 1411713135, Iran.
Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 1985711151, Iran.
出版信息
Biomed Res Int. 2014;2014:481607. doi: 10.1155/2014/481607. Epub 2014 Jun 17.
BACKGROUND
The aim of this investigation is to study the relationship between gastric morphology and serum biomarkers before and after Helicobacter pylori eradication.
METHODS
First-degree relatives of gastric cancer patients underwent gastroscopy before and 2.5 years after H. pylori eradication. The morphological changes in two categories (normal to mild and moderate to severe) were compared with level of pepsinogens I and II before eradication (n = 369), after eradication (n = 115), and in those with persistent infection (n = 250).
RESULTS
After eradication, pepsinogen I decreased to 70% and pepsinogen II to 45% of the previous values. Unlike pepsinogen II and pepsinogen I to II ratio that were affected by the severity of inflammation and atrophy in corpus in all groups, pepsinogen I generally did not change. After eradication, subjects with high mononuclear infiltration in corpus had lower pepsinogen I (54 versus 77.1 μ/mL), higher pepsinogen II (9.4 versus 6.9 μ/mL), and lower ratio (7.9 versus 11.6) than those without (P < 0.05).
CONCLUSION
Pepsinogen II is a good marker of corpus morphological changes before and after H. pylori eradication.
背景
本研究旨在探讨幽门螺杆菌（H. pylori）根除前后胃形态与血清生物标志物之间的关系。
方法
胃癌患者的一级亲属在 H. pylori 根除前和根除后 2.5 年进行胃镜检查。将两类形态变化（正常至轻度和中度至重度）与根除前（n=369）、根除后（n=115）和持续感染（n=250）时的胃蛋白酶原 I 和 II 水平进行比较。
结果
根除后，胃蛋白酶原 I 降至根除前的 70%，胃蛋白酶原 II 降至 45%。与胃体炎症和萎缩程度均影响胃蛋白酶原 II 和胃蛋白酶原 I 比值不同，胃蛋白酶原 I 一般不变。根除后，胃体单核细胞浸润较高者的胃蛋白酶原 I 较低（54 比 77.1 μ/mL），胃蛋白酶原 II 较高（9.4 比 6.9 μ/mL），比值较低（7.9 比 11.6）（P<0.05）。
结论
胃蛋白酶原 II 是 H. pylori 根除前后胃体形态变化的良好标志物。
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