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伯明翰髋关节表面置换术十年随访结果:常规全血金属离子检测在假肿瘤筛查中的作用

Outcome of Birmingham hip resurfacing at ten years: role of routine whole blood metal ion measurements in screening for pseudotumours.

作者信息

Reito Aleksi, Puolakka Timo, Elo Petra, Pajamäki Jorma, Eskelinen Antti

机构信息

Coxa Hospital for Joint Replacement, P.O. Box 652, 33101, Tampere, Finland,

出版信息

Int Orthop. 2014 Nov;38(11):2251-7. doi: 10.1007/s00264-014-2429-4. Epub 2014 Jul 17.

Abstract

PURPOSE

Emerging concern has arisen because of recent papers reporting a high prevalence of pseudotumours (PTs), even in patients with surface arthroplasties with a good clinical track record. The aim of our study was to establish the ten year survivorship of Birmingham hip resurfacing (BHR), to investigate whole blood (WB) metal ion levels and prevalence of adverse reactions to metal debris (ARMeD) and to determine the association of blood metal ion levels and symptoms with ARMeD in patients operated on with BHR at our institution.

METHODS

Between May 2001 and May 2004, 261 consecutive BHRs were implanted in 219 patients. All living, nonrevised patients underwent a systematic screening programme consisting of clinical examination, WB cobalt and chromium measurements and targeted cross-sectional imaging.

RESULTS

The ten year survival for the entire cohort was 91% (89-93%), with any revision as the endpoint. Prevalence of ARMeD was 6.9% in male and 8.8% in female patients. Symptomatic patients with elevated metal ion levels evinced highest prevalence (63%) of PTs compared with asymptomatic patients with elevated metal ion levels (42%) and symptomatic patients with nonelevated metal ions (11%).

CONCLUSIONS

Contradicting the current international guidelines, our results suggest that it seems beneficial to combine routine metal ion measurement with clinical assessment, even in patients with well-functioning BHRs. Further follow-up will reveal whether new PTs will develop in these patients and BHR survivorship in the longer term.

摘要

目的

近期有论文报道了假肿瘤(PTs)的高患病率,甚至在临床记录良好的表面置换患者中也是如此,这引发了新的关注。我们研究的目的是确定伯明翰髋关节表面置换术(BHR)的十年生存率,调查全血(WB)金属离子水平及金属碎屑不良反应(ARMeD)的患病率,并确定在我们机构接受BHR手术的患者中,血液金属离子水平和症状与ARMeD之间的关联。

方法

在2001年5月至2004年5月期间,连续为219例患者植入了261个BHR。所有存活且未翻修的患者都接受了一个系统的筛查项目,包括临床检查、WB钴和铬测量以及针对性的横断面成像。

结果

以任何翻修为终点,整个队列的十年生存率为91%(89 - 93%)。男性患者中ARMeD的患病率为6.9%,女性患者为8.8%。与金属离子水平升高但无症状的患者(42%)以及金属离子水平未升高但有症状的患者(11%)相比,金属离子水平升高且有症状的患者中PTs的患病率最高(63%)。

结论

与当前国际指南相反,我们的结果表明,即使对于功能良好的BHR患者,将常规金属离子测量与临床评估相结合似乎也是有益的。进一步的随访将揭示这些患者是否会出现新的PTs以及BHR的长期生存率。

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