Global T-wave inversion on electrocardiogram: what is the differential?

Global T-wave inversion as seen on electrocardiogram is associated with a variety of pathophysiologic states, including cardiac, pulmonary, and cerebrovascular disease, and acute electrolyte disorders. Although some of these are chronic conditions, others are acute emergencies, necessitating early diagnosis and treatment. This article reviews and provides examples of possible etiologies of global T-wave inversion on electrocardiogram.