Krejčí H, Anderlová K
Ceska Gynekol. 2014 Jun;79(3):206-12.
Gestational diabetes mellitus (GDM) is the most common internal complication in pregnancy and similarly as the frequency of Type 2 diabetes rises in general population so does the frequency of GDM. The causes include unhealthy life style, growing incidence of overweight and obesity as well as older age of pregnant women. Older data reported the frequency of GDM in 3-4% of all pregnancies in the Czech Republic, whereas nowadays its frequency with using the same diagnostic criteria is more than two times higher. If we include the measurement of glycemia in 1 hour of oGTT, the frequency of GDM reaches more than 20%. In case we accept the new recommendation of the International Association for Diabetes in Pregnancy Study Groups (IADPSG), it is expected that the frequency of GDM will be even higher. IADPSG recommendation resulted from HAPO study (Hyperglycemia and Adverse Pregnancy Outcomes), a large international observational study on the relationship between mild hyperglycemia and pregnancy outcomes. Adoption of these new criteria is intensively discussed among experts all over the world. WHO adopted the IADPSG criteria in 2013. The Czech Diabetes Society committee adopted them in April 2014. Any official statement about the new criteria has not yet been issued by the Czech Gynecology and Obstetrics Society. This article analyzes the old and the new diagnostic criteria, summarizes the most common arguments in favor and against the IADPSG thresholds and tries to open the discussion about this important topic.
妊娠期糖尿病(GDM)是妊娠期间最常见的内科并发症,与2型糖尿病在普通人群中的发病率上升类似,GDM的发病率也在上升。其病因包括不健康的生活方式、超重和肥胖发生率的增加以及孕妇年龄增大。较早的数据显示,在捷克共和国,所有妊娠中GDM的发病率为3%-4%,而如今采用相同的诊断标准,其发病率高出两倍多。如果将口服葡萄糖耐量试验(oGTT)1小时血糖测量值纳入,GDM的发病率将超过20%。如果我们接受国际妊娠糖尿病研究组(IADPSG)的新建议,预计GDM的发病率会更高。IADPSG的建议源于高血糖与不良妊娠结局(HAPO)研究,这是一项关于轻度高血糖与妊娠结局关系的大型国际观察性研究。世界各地的专家都在深入讨论采用这些新标准的问题。世界卫生组织于2013年采用了IADPSG标准。捷克糖尿病学会委员会于2014年4月采用了这些标准。捷克妇产科协会尚未就新标准发表任何官方声明。本文分析了新旧诊断标准,总结了支持和反对IADPSG阈值的最常见论点,并试图开启关于这一重要话题的讨论。