组织学和细胞学在肌肉骨骼肿瘤诊断中的有效性。

Effectiveness of histology and cytology on musculoskeletal tumor diagnosis.

作者信息

Lima Pablo Moura de Andrade, Oliveira Marcelo Parente, Ferreira George Rocha, Lima Túlio Paes de Medeiros, Lima Jairo de Andrade, de Mello Roberto José Vieira

机构信息

1. Orthopedic and Traumatology Service, Hospital das Clínicas, UFPE, Recife, PE, Brazil, 1. Orthopedic and Traumatology Service, Hospital das Clínicas, UFPE, Recife, PE, Brazil, UFPE, Hospital das Clínicas, Recife, PE, Brazil.

2. Hospitais Agamenon Magalhães, 2. Hospitais Agamenon Magalhães, Hospitais Agamenon Magalhães.

出版信息

Acta Ortop Bras. 2014;22(3):132-5. doi: 10.1590/1413-78522014220300440.

DOI:10.1590/1413-78522014220300440

PMID:25061418

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4108694/

Abstract

OBJECTIVE

To compare cytology and histology on the diagnosis of musculoskeletal neoplasms.

METHOD

Fifty eight cases available to evaluation were analyzed both by cytology and histology. The results of the biopsies studied by histology and cytology were compared to the results obtained on the surgical specimen or immunohistochemistry. We determined the percentage of correct results, sensitivity, specificity, positive and negative predictive values and accuracy of each method.

RESULTS

Twelve per cent of biopsies were inconclusive by cytology. The percentage of correct diagnosis was 70.7% and 81% (p=.179), the ability to differentiate benign lesions from malignant ones was 84.5% and 93.1% (p=0.18) respectively, for cytology and histology. Cytology showed sensitivity of 87.8%, specificity of 76.5%, positive predictive value of 90%, negative predictive value of 72% and accuracy 84.5%. Histology showed sensitivity of 90.2%, specificity of 100%, positive predictive value of 100%, negative predictive value of 81% and accuracy of 93.1%. The Youden index for cytology was 64.3% and for histology it was 90.2%.

CONCLUSION

Despite promising, cytology obtained by thin needle aspiration is less accurate and reliable than the histological evaluation on musculoskeletal tumors diagnosis.

摘要

目的

比较细胞学和组织学在肌肉骨骼肿瘤诊断中的应用。

方法

对58例可供评估的病例进行了细胞学和组织学分析。将组织学和细胞学活检结果与手术标本或免疫组织化学结果进行比较。我们确定了每种方法的正确结果百分比、敏感性、特异性、阳性和阴性预测值以及准确性。

结果

12%的活检细胞学结果不明确。细胞学和组织学的正确诊断率分别为70.7%和81%（p = 0.179），区分良性病变和恶性病变的能力分别为84.5%和93.1%（p = 0.18）。细胞学的敏感性为87.8%，特异性为76.5%，阳性预测值为90%，阴性预测值为72%，准确性为84.5%。组织学的敏感性为90.2%，特异性为100%，阳性预测值为100%，阴性预测值为81%，准确性为93.1%。细胞学的约登指数为64.3%，组织学的约登指数为90.2%。